OBJECTIVES: This study was designed to assess effects of cholinergic stimulation using acetylcholinesterase inhibitors (AChEIs), a group of drugs that stimulate cholinergic receptors and are used to treat Alzheimer's disease (AD), on healing of hip fractures. METHODS: A retrospective cohort study was performed using 46-female AD patients, aged above 75 years, who sustained hip fractures. Study analyses included the first 6-months after hip fracture fixation procedure. Presence of AChEIs was used as predictor variable. Other variables that could affect study outcomes: age, body mass index (BMI), mental state or type of hip fracture, were also included. Radiographic union at fracture site (Hammer index), bone quality (Singh index) and fracture healing complications were recorded as study outcomes. The collected data was analyzed by student's-t, Mann-Whitney-U and chi-square tests. RESULTS: No significant differences in age, BMI, mental state or type of hip fracture were observed between AChEIs-users and nonusers. However, AChEIs-users had better radiographic union at the fracture site (relative risk (RR),2.7; 95%confidence interval (CI),0.9-7.8), better bone quality (RR,2.0; 95%CI,1.2-3.3) and fewer healing complications (RR,0.8; 95%CI,0.7-1.0) than nonusers. CONCLUSION: In elderly female patients with AD, the use of AChEIs might be associated with an enhanced fracture healing and minimized complications.
OBJECTIVES: This study was designed to assess effects of cholinergic stimulation using acetylcholinesterase inhibitors (AChEIs), a group of drugs that stimulate cholinergic receptors and are used to treat Alzheimer's disease (AD), on healing of hip fractures. METHODS: A retrospective cohort study was performed using 46-female ADpatients, aged above 75 years, who sustained hip fractures. Study analyses included the first 6-months after hip fracture fixation procedure. Presence of AChEIs was used as predictor variable. Other variables that could affect study outcomes: age, body mass index (BMI), mental state or type of hip fracture, were also included. Radiographic union at fracture site (Hammer index), bone quality (Singh index) and fracture healing complications were recorded as study outcomes. The collected data was analyzed by student's-t, Mann-Whitney-U and chi-square tests. RESULTS: No significant differences in age, BMI, mental state or type of hip fracture were observed between AChEIs-users and nonusers. However, AChEIs-users had better radiographic union at the fracture site (relative risk (RR),2.7; 95%confidence interval (CI),0.9-7.8), better bone quality (RR,2.0; 95%CI,1.2-3.3) and fewer healing complications (RR,0.8; 95%CI,0.7-1.0) than nonusers. CONCLUSION: In elderly female patients with AD, the use of AChEIs might be associated with an enhanced fracture healing and minimized complications.
Authors: Abayomi N Ogunwale; Cathleen S Colon-Emeric; Richard Sloane; Robert A Adler; Kenneth W Lyles; Richard H Lee Journal: J Bone Miner Res Date: 2019-12-12 Impact factor: 6.741
Authors: Robert Josef Nachlinger; Vivien Kauschke; Katja Trinkaus; Thaqif El Khassawna; Christian Heiss; Katrin Susanne Lips Journal: J Musculoskelet Neuronal Interact Date: 2018-09-01 Impact factor: 2.041
Authors: I Tamimi; S A Madathil; A Kezouh; B Nicolau; I Karp; F Tamimi Journal: J Musculoskelet Neuronal Interact Date: 2017-06-01 Impact factor: 2.041
Authors: Faez Saleh Al-Hamed; Ola M Maria; Jeff Phan; Ahmed Al Subaie; Qiman Gao; Alaa Mansour; Lina Abu Nada; Imane Boukhatem; Osama A Elkashty; Simon D Tran; Marie Lordkipanidzé; Zahi Badran; Faleh Tamimi Journal: Biomolecules Date: 2020-09-14