Christoph Liebetrau1, Luise Gaede2, Oliver Dörr3, Christian Troidl2, Sandra Voss2, Jedrzej Hoffmann2, Agata Paszko2, Michael Weber2, Andreas Rolf2, Christian Hamm4, Holger Nef3, Helge Möllmann2. 1. Kerckhoff Heart and Thorax Center, Department of Cardiology, Bad Nauheim, Germany; DZHK (German Centre for Cardiovascular Research), partner site RheinMain, Bad Nauheim, Germany; Justus Liebig University Giessen, Department of Internal Medicine I, Division of Cardiology, Giessen, Germany. Electronic address: c.liebetrau@kerckhoff-klinik.de. 2. Kerckhoff Heart and Thorax Center, Department of Cardiology, Bad Nauheim, Germany; DZHK (German Centre for Cardiovascular Research), partner site RheinMain, Bad Nauheim, Germany. 3. Justus Liebig University Giessen, Department of Internal Medicine I, Division of Cardiology, Giessen, Germany. 4. Kerckhoff Heart and Thorax Center, Department of Cardiology, Bad Nauheim, Germany; DZHK (German Centre for Cardiovascular Research), partner site RheinMain, Bad Nauheim, Germany; Justus Liebig University Giessen, Department of Internal Medicine I, Division of Cardiology, Giessen, Germany.
Abstract
BACKGROUND: N-terminal segment of B-type natriuretic peptide prohormone (NT-proBNP) is elevated in patients with acute myocardial infarction (AMI) thus providing both diagnostic information and prognostic information. The aim of the present study was to determine the time course of NT-proBNP release in patients undergoing transcoronary ablation of septal hypertrophy (TASH) a procedure mimicking AMI. METHODS: We analyzed the release kinetics of NT-proBNP in 18 consecutive patients with hypertrophic obstructive cardiomyopathy undergoing TASH. Serum samples were collected prior to and at 15, 30, 45, 60, 75, 90, and 105 min, and 2, 4, 8, and 24h after TASH. RESULTS: NT-proBNP concentrations showed a continuous increase during the first 75 min with a significant percent change compared to baseline value already 15 min after TASH (105.6% [IQR 102.2-112.7]; P<0.001). All patients had a significant increase of NT-proBNP at 45 min (range of percent increase [min-max]: 103.5-137.2%; range of absolute increase [min-max]: 23.5-304.0 ng/L). NT-proBNP concentrations decreased below the baseline value until the 8th h after initiation of myocardial infarction. CONCLUSION: NT-proBNP concentration increases immediately after induction of myocardial infarction proving early evidence of myocardial injury despite the decrease of the left ventricular wall stress due to the TASH related reduction of the left ventricular outflow gradient.
BACKGROUND: N-terminal segment of B-type natriuretic peptide prohormone (NT-proBNP) is elevated in patients with acute myocardial infarction (AMI) thus providing both diagnostic information and prognostic information. The aim of the present study was to determine the time course of NT-proBNP release in patients undergoing transcoronary ablation of septal hypertrophy (TASH) a procedure mimicking AMI. METHODS: We analyzed the release kinetics of NT-proBNP in 18 consecutive patients with hypertrophic obstructive cardiomyopathy undergoing TASH. Serum samples were collected prior to and at 15, 30, 45, 60, 75, 90, and 105 min, and 2, 4, 8, and 24h after TASH. RESULTS: NT-proBNP concentrations showed a continuous increase during the first 75 min with a significant percent change compared to baseline value already 15 min after TASH (105.6% [IQR 102.2-112.7]; P<0.001). All patients had a significant increase of NT-proBNP at 45 min (range of percent increase [min-max]: 103.5-137.2%; range of absolute increase [min-max]: 23.5-304.0 ng/L). NT-proBNP concentrations decreased below the baseline value until the 8th h after initiation of myocardial infarction. CONCLUSION: NT-proBNP concentration increases immediately after induction of myocardial infarction proving early evidence of myocardial injury despite the decrease of the left ventricular wall stress due to the TASH related reduction of the left ventricular outflow gradient.
Authors: Thomas L Lynch; Diederik W D Kuster; Beverly Gonzalez; Neelam Balasubramanian; Nandini Nair; Sharlene Day; Jenna E Calvino; Yanli Tan; Christoph Liebetrau; Christian Troidl; Christian W Hamm; Ahmet Güçlü; Barbara McDonough; Ali J Marian; Jolanda van der Velden; Christine E Seidman; Gordon S Huggins; Sakthivel Sadayappan Journal: JACC Basic Transl Sci Date: 2016-12-19
Authors: Steffen D Kriechbaum; Christoph B Wiedenroth; Till Keller; Jan Sebastian Wolter; Ruth Ajnwojner; Karina Peters; Moritz A Haas; Fritz C Roller; Andreas Breithecker; Andreas J Rieth; Stefan Guth; Andreas Rolf; Dirk Bandorski; Christian W Hamm; Eckhard Mayer; Christoph Liebetrau Journal: PLoS One Date: 2018-09-25 Impact factor: 3.240