| Literature DB >> 24291040 |
Laurent Hortala1, Joëlle Arnaud1, Pascale Roux1, Didier Oustric1, Laurent Boulu1, Florence Oury-Donat1, Patrick Avenet2, Thomas Rooney3, David Alagille4, Olivier Barret4, Gilles Tamagnan4, Francis Barth5.
Abstract
Cannabinoid CB2 PET tracers are considered as a promising alternative to PBR/TSPO tracers for the in-vivo imaging of neuroinflammation. We describe here the synthesis and characterization of compound 3, a new potent and brain penetrating CB2 ligand based on an original triazine template. The PET tracer [(18)F]-dideutero-3 was prepared in a three steps radiosynthesis, and demonstrated significant uptake in rhesus macaque and baboon brain with a maximum SUV of about 0.7-0.9g/mL, followed by a moderate washout over time.Entities:
Keywords: CB2; Cannabinoid; Imaging; PET; Triazine
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Year: 2013 PMID： 24291040 DOI： 10.1016/j.bmcl.2013.11.023
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823