| Literature DB >> 24290968 |
Hideaki Watanabe1, Ichiro Kikkawa1, Seiji Madoiwa2, Hitoshi Sekiya1, Shinya Hayasaka3, Yoichi Sakata2.
Abstract
This study investigated changes in blood coagulation-fibrinolysis markers during total knee arthroplasty (TKA). Preoperative 16-row multidetector row computed tomography (MDCT) revealed no asymptomatic venous thromboembolism (VTE) in the 42 patients recruited. Using MDCT postoperatively, patients were divided into thrombus (asymptomatic VTE, 19 patients) and no-thrombus (23 patients) groups. Blood taken at intervals before and after pneumatic tourniquet release revealed increased plasminogen activator inhibitor type-1 (PAI-1) at 30s for both groups and at 90s (both P=0.01) in the thrombus group. D-dimer levels were highest at 30 and 90s for both groups (P = 0.01). PAI-1 and D-dimer levels were strongly correlated at both time points in the thrombus group. Inactivating fibrinolysis due to PAI-1 may lead to asymptomatic VTE after TKA.Entities:
Keywords: cross-linked fibrin degradation products by leukocyte elastase (e-XDP); d-dimer; plasminogen activator inhibitor type 1; soluble fibrin monomer complex; total knee arthroplasty; venous thromboembolism
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Year: 2013 PMID： 24290968 DOI： 10.1016/j.arth.2013.08.011
Source DB: PubMed Journal: J Arthroplasty ISSN： 0883-5403 Impact factor: 4.757