| Literature DB >> 24290813 |
Xianting Huang1, Yuchan Wang1, Xun Nan1, Song He2, Xiaohong Xu2, Xinghua Zhu2, Jie Tang1, Xiaojing Yang1, Li Yao1, Xinxiu Wang1, Chun Cheng3.
Abstract
The orphan G protein-coupled receptor 37 (GPR37) is homologous to endothelin (ETB-R) and bombesin (GRP-R, NMB-R) receptors. The present study was undertaken to determine the expression and functional significance of GPR37 in human multiple myeloma (MM). We found that GPR37 was lowly expressed in MM cell adhesion model and highly expressed in proliferating cells. In vitro, meddling with the expression of GPR37 affected the CAM-DR by regulating the ability of cell adhesion and the activity of Akt and ERK in MM cells. Further studies indicated the positive role of GPR37 in the proliferation of MM cells.Entities:
Keywords: CAM-DR; GPR37; MAPK/ERK; PI3K/Akt; Proliferation
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Year: 2013 PMID： 24290813 DOI： 10.1016/j.leukres.2013.11.007
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156