| Literature DB >> 24290471 |
Xian Yang1, Chong-Gang Huang2, Shou-Ying Du3, Shui-Ping Yang4, Xue Zhang2, Jian-Yi Liu2, Jia-Hong Xu2.
Abstract
To investigate the pharmacological effects of Danggui Buxue Tang (DBT) on immune-mediated aplasia anemia mice. The model of immune-mediated aplasia anemia mice was induced by means of (60)Co γ-ray irradiation and mixed cells of thymus and lymphnode of DBA/2 mice infusion through tail vein, the parameters tested indices were as following: blood picture, bone marrow nucleated cell count (BMNC), murine colony-forming unit-megakaryocytes (CFU-GM) of bone marrow cells, murine colony-forming unit-erthroid (CFU-E) and burst forming unit-erythroid (BFU-E). The results showed that DBT could not only withstand significantly decreation of blood cells by immune-mediated, but also stimulate on the growth of bone marrow colony cell and increase the weight of hemopoietic progenitor of bone marrow. Therefore, DBT had an obvious treat effect on immune-mediated aplasia anemia models mice.Entities:
Keywords: Aplastic anemia mice; Bone marrow colony cell; Danggui Buxue Tang; Immune-mediated; TCM Formula
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Year: 2013 PMID： 24290471 DOI： 10.1016/j.phymed.2013.10.018
Source DB: PubMed Journal: Phytomedicine ISSN： 0944-7113 Impact factor: 5.340