| Literature DB >> 24290064 |
Naoki Takahashi1, Koji Maeda1, Yukiyasu Asano2, Nobuhide Watanabe3.
Abstract
A series of 1-benzylindole-based TRβ agonists were prepared and evaluated. Compounds 11b' and 11c' were found to have cholesterol-lowering in a rat model with marginal effects on cardiac function and HPT axis. The present work illustrates the potential use of indoles as inner ring isosteres.Entities:
Keywords: Dyslipidemia; Hypothalamic/pituitary/thyroid axis; Thyroid hormone receptor β agonists; Thyroid stimulating hormone
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Year: 2013 PMID： 24290064 DOI： 10.1016/j.bmc.2013.11.001
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641