| Literature DB >> 24290033 |
Tine Hvarness1, John E Nielsen, Kristian Almstrup, Niels E Skakkebaek, Ewa Rajpert-De Meyts, Mogens H Claesson.
Abstract
Immune cells often infiltrate testicular germ cell neoplasms, including pre-invasive carcinoma in situ (CIS), but the significance of this phenomenon remains unknown. The composition and distribution of infiltrating immune cells were examined by immunohistochemistry in testis samples with CIS and overt seminoma, in comparison to biopsies from infertile men without neoplasia. The composition of immune cells was similar across all the groups studied. Macrophages, CD8⁺ and CD45R0⁺ T lymphocytes constituted the majority of infiltrates, B lymphocytes were present in an intermediate proportion and very few CD4⁺ and FoxP3⁺ T cells were detected. HLA-I antigen was more abundant in Sertoli cells in tubules containing CIS than in those with normal spermatogenesis. This study showed a phenotypically comparable composition of infiltrating immune cells independently of the presence of neoplasia, suggesting the absence of active immune surveillance in testicular germ cell cancer.Entities:
Keywords: Carcinoma in situ; Germ cell tumour; Immune cell infiltration; Immune privilege; Immune surveillance; Testis
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Year: 2013 PMID： 24290033 DOI： 10.1016/j.jri.2013.10.005
Source DB: PubMed Journal: J Reprod Immunol ISSN： 0165-0378 Impact factor: 4.054