Su Kyoung Kwon1, Sung Hoon Kim2, Sung-Cheol Yun3, Dae Yeon Kim1, Hee Dong Chae1, Chung-Hoon Kim1, Byung Moon Kang1. 1. Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea. 2. Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea. Electronic address: kimsung@amc.seoul.kr. 3. Division of Biostatistics, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea.
Abstract
OBJECTIVE: To identify the most important factor in predicting ovarian reserve after laparoscopic ovarian cystectomy and to evaluate whether there is any difference in the postoperative decline of ovarian reserve between women with endometrioma and those with other benign ovarian cysts. DESIGN: Prospective cohort study. SETTING: University hospital. PATIENT(S): A total of 100 women who had undergone laparoscopic ovarian cystectomy for endometrioma (n = 68) or other benign ovarian cysts (n = 32). INTERVENTION(S): Serum antimüllerian hormone (AMH) levels measured by enzyme immunoassay preoperatively and at 3 months after surgery. MAIN OUTCOME MEASURE(S): Rate of AMH decline after surgery and follicle numbers retained in cystectomy specimens. RESULT(S): Serum AMH levels were obviously decreased at 3 months after the surgery (4.97 ± 2.83 vs. 3.33 ± 2.08 ng/mL, mean ± standard deviation). Adjusting for several parameters, we could see that bilaterality of the ovarian cyst was the only significant factor in predicting the rate of postoperative decline of AMH levels. The rate of AMH decline did not differ between the endometrioma group and the other benign ovarian cyst group. CONCLUSION(S): Bilaterality of the ovarian cyst is the only significant factor in predicting the rate of decline of AMH level after laparoscopic ovarian cystectomy. The rate of decline of AMH levels after surgery was similar between the endometrioma group and the other benign ovarian cyst group.
OBJECTIVE: To identify the most important factor in predicting ovarian reserve after laparoscopic ovarian cystectomy and to evaluate whether there is any difference in the postoperative decline of ovarian reserve between women with endometrioma and those with other benign ovarian cysts. DESIGN: Prospective cohort study. SETTING: University hospital. PATIENT(S): A total of 100 women who had undergone laparoscopic ovarian cystectomy for endometrioma (n = 68) or other benign ovarian cysts (n = 32). INTERVENTION(S): Serum antimüllerian hormone (AMH) levels measured by enzyme immunoassay preoperatively and at 3 months after surgery. MAIN OUTCOME MEASURE(S): Rate of AMH decline after surgery and follicle numbers retained in cystectomy specimens. RESULT(S): Serum AMH levels were obviously decreased at 3 months after the surgery (4.97 ± 2.83 vs. 3.33 ± 2.08 ng/mL, mean ± standard deviation). Adjusting for several parameters, we could see that bilaterality of the ovarian cyst was the only significant factor in predicting the rate of postoperative decline of AMH levels. The rate of AMH decline did not differ between the endometrioma group and the other benign ovarian cyst group. CONCLUSION(S): Bilaterality of the ovarian cyst is the only significant factor in predicting the rate of decline of AMH level after laparoscopic ovarian cystectomy. The rate of decline of AMH levels after surgery was similar between the endometrioma group and the other benign ovarian cyst group.
Authors: Charmaine A Cabiscuelas; Lan Ying Li; Ki Eun Seon; Yup Kim; Jae Hoon Lee; Eun Ji Nam; Jung-Yun Lee; Sunghoon Kim; Young Tae Kim; Sang Wun Kim Journal: J Menopausal Med Date: 2021-12