| Literature DB >> 24289956 |
Emanuel Della-Torre1, Laura Galli2, Diego Franciotta3, Enrica Paola Bozzolo4, Chiara Briani5, Roberto Furlan6, Luisa Roveri7, Maria Sessa7, Gabriella Passerini8, Maria Grazia Sabbadini9.
Abstract
Diagnosis of IgG4-Related Hypertrophic Pachymeningitis (IgG4-HP) relies on meningeal biopsies, because cerebrospinal fluid (CSF) diagnostic biomarkers are lacking. Here, we determined whether IgG4 intrathecal production could distinguish IgG4-HP from other disorders presenting with HP (OHP). In patients with IgG4-HP, the median CSF IgG4 concentration, IgG4 Index and IgG4Loc were significantly higher than in both controls and OHP. CSF IgG4 levels higher than 2.27mg/dL identified 100% of IgG4-HP and 5% of OHP. An IgG4Loc cut-off of 0.47 identified 100% of IgG4-HP and no cases of OHP. Our results support CSF IgG4 quantification and IgG4 Indices as alternatives to meningeal biopsy for the diagnosis of IgG4-HP when this procedure is contraindicated or uninformative.Entities:
Keywords: Cerebrospinal fluid; Hypertrophic pachymeningitis; IgG4; IgG4-related disease; IgG4-related pachymeningitis; Pachymeningitis
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Year: 2013 PMID： 24289956 DOI： 10.1016/j.jneuroim.2013.10.008
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478