Suleyman Guven1, Cavit Kart2, Mesut A Unsal2, Ozkan Yildirim2, Ersan Odaci2, Esin Yulug2. 1. Karadeniz Technical University, Faculty of Medicine, Department of Obstetrics and Gynaecology, Farabi ART Centre, Trabzon, Turkey. Electronic address: drsuleymanguven@yahoo.com. 2. Karadeniz Technical University, Faculty of Medicine, Department of Obstetrics and Gynaecology, Farabi ART Centre, Trabzon, Turkey.
Abstract
OBJECTIVE: To investigate the effect of endometrial injury on the clinical pregnancy rate in normoresponders undergoing long agonist protocol intracytoplasmic sperm injection (ICSI) cycles with single embryo transfer. STUDY DESIGN: Prospective case-control study. METHODS: One hundred and eighteen women (age <35 years, normoresponders with Grade I or II embryos for transfer) were included. Women in the intervention group (n=56) underwent endometrial biopsy on Day 3 of the menstrual cycle following downregulation. Women in the control group (n=62) did not undergo endometrial biopsy. RESULTS: The clinical and embryological characteristics were comparable in the two groups, and no significant difference was found in the fertilization rates (66.32% in the intervention group vs. 70.23% in the control group). The clinical pregnancy rate was 48.2% in the intervention group and 29.0% in the control group (p=0.025). Endometrial injury may increase the clinical pregnancy rate (odds ratio 2.27). The 'take home baby' rates were 33.9% and 17.7% in the intervention and control groups, respectively (p=0.035). CONCLUSION: Assisted reproductive technology treatment that is preceded by endometrial injury may increase the clinical pregnancy rate in women undergoing long agonist protocol ICSI cycles with single embryo transfer.
OBJECTIVE: To investigate the effect of endometrial injury on the clinical pregnancy rate in normoresponders undergoing long agonist protocol intracytoplasmic sperm injection (ICSI) cycles with single embryo transfer. STUDY DESIGN: Prospective case-control study. METHODS: One hundred and eighteen women (age <35 years, normoresponders with Grade I or II embryos for transfer) were included. Women in the intervention group (n=56) underwent endometrial biopsy on Day 3 of the menstrual cycle following downregulation. Women in the control group (n=62) did not undergo endometrial biopsy. RESULTS: The clinical and embryological characteristics were comparable in the two groups, and no significant difference was found in the fertilization rates (66.32% in the intervention group vs. 70.23% in the control group). The clinical pregnancy rate was 48.2% in the intervention group and 29.0% in the control group (p=0.025). Endometrial injury may increase the clinical pregnancy rate (odds ratio 2.27). The 'take home baby' rates were 33.9% and 17.7% in the intervention and control groups, respectively (p=0.035). CONCLUSION: Assisted reproductive technology treatment that is preceded by endometrial injury may increase the clinical pregnancy rate in women undergoing long agonist protocol ICSI cycles with single embryo transfer.
Authors: Marie D Werner; Eric J Forman; Kathleen H Hong; Jason M Franasiak; Paul A Bergh; Richard T Scott Journal: J Assist Reprod Genet Date: 2015-01-28 Impact factor: 3.412
Authors: N E van Hoogenhuijze; H L Torrance; F Mol; J S E Laven; E Scheenjes; M A F Traas; C Janssen; B Cohlen; G Teklenburg; J P de Bruin; R van Oppenraaij; J W M Maas; E Moll; K Fleischer; M H van Hooff; C de Koning; A Cantineau; C B Lambalk; M Verberg; M Nijs; A P Manger; M van Rumste; L F van der Voet; A Preys-Bosman; J Visser; E Brinkhuis; J E den Hartog; A Sluijmer; F W Jansen; W Hermes; M L Bandell; M J Pelinck; J van Disseldorp; M van Wely; J Smeenk; Q D Pieterse; J C Boxmeer; E R Groenewoud; M J C Eijkemans; J C Kasius; F J M Broekmans Journal: BMC Womens Health Date: 2017-07-21 Impact factor: 2.809
Authors: Sarah F Lensen; Sarah Armstrong; Ahmed Gibreel; Carolina O Nastri; Nick Raine-Fenning; Wellington P Martins Journal: Cochrane Database Syst Rev Date: 2021-06-10