| Literature DB >> 24288276 |
Viviane Rodrigues Esperandim1, Daniele da Silva Ferreira, Karen Cristina Sousa Rezende, Lizandra Guidi Magalhães, Julia Medeiros Souza, Patrícia Mendonça Pauletti, Ana Helena Januário, Rosangela da Silva de Laurentz, Jairo Kenupp Bastos, Guilherme Venâncio Símaro, Wilson Roberto Cunha, Márcio Luis Andrade E Silva.
Abstract
Protozoans of the trypanosomatid family cause the neglected tropical diseases leishmaniasis and trypanosomiasis, for which few drugs are available. In this context our group has recently reported that the essential oil obtained by steam distillation of the fruits of Piper cubeba is active against Schistosoma mansoni. Therefore, we have investigated the in vitro effects of the essential oil against the trypomastigote and amastigote forms of Trypanosoma cruzi isolated from an LLCMK₂ cell line culture and the promastigote forms of Leishmania amazonensis. The in vitro activity of the essential oil against trypomastigotes of T. cruzi increased upon rising concentrations, giving IC₅₀ values of 45.5 and 87.9 µg · mL⁻¹ against trypomastigotes and amastigotes, respectively. The essential oil was not active against L. amazonensis, since it displayed lyses of only 24 % at 400 µg · mL⁻¹, and an IC₅₀ of 326.5 µg · mL⁻¹. Therefore, the essential oil should be further investigated to determine the compounds responsible for the observed activities, as well as its mechanism of action. Georg Thieme Verlag KG Stuttgart · New York.Entities:
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Year: 2013 PMID： 24288276 DOI： 10.1055/s-0033-1351022
Source DB: PubMed Journal: Planta Med ISSN： 0032-0943 Impact factor: 3.352