| Literature DB >> 2428759 |
E Oosterwijk, D J Ruiter, P J Hoedemaeker, E K Pauwels, U Jonas, J Zwartendijk, S O Warnaar.
Abstract
This report describes a monoclonal antibody designated G 250, subclass IgGl, that recognizes an antigen preferentially expressed on cell membranes of renal-cell carcinoma cells (RCC) and not expressed in normal proximal tubular epithelium. G 250 antibody reacted with 46 of 47 primary RCC, with 7 of 8 RCC metastases and with a few other malignant tumors. The staining pattern of G 250 differs from that of other RCC-related antibodies described. Preliminary experiments show that this antibody can be used to visualize RCC xenografts in nude mice by immunoscintigraphy.Entities:
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Year: 1986 PMID： 2428759 DOI： 10.1002/ijc.2910380406
Source DB: PubMed Journal: Int J Cancer ISSN： 0020-7136 Impact factor: 7.396