Ying-Wei Qiu1, Xiao-Fei Lv2, Gui-Hua Jiang3, Huan-Huan Su3, Tian Yu3, Jun-Zhang Tian3, Xue-Lin Zhang4, Fu-Zhen Zhuo5. 1. Department of Medical Imaging, Guangdong No. 2 Provincial People's Hospital, Guangzhou 510317, PR China. Electronic address: qiuyw1201@gmail.com. 2. Department of Medical Imaging, Guangdong No. 2 Provincial People's Hospital, Guangzhou 510317, PR China; Department of Medical Imaging and Interventional Radiology, Cancer Center, Sun Yat-Sen University, Guangzhou 510060, PR China. 3. Department of Medical Imaging, Guangdong No. 2 Provincial People's Hospital, Guangzhou 510317, PR China. 4. Medical Imaging Centre, NanFang Hospital, Southern Medial University, Guangzhou 510515, PR China. 5. Addiction Medicine Division, Guangdong No. 2 Provincial People's Hospital, Guangzhou 510317, PR China.
Abstract
OBJECTIVE: To characterize the association between clinical symptoms and anatomical and functional cerebral deficits in codeine-containing cough syrups (CCS) users using voxel-based morphometry and resting state functional connectivity analysis. METHODS:Participants were 30 CCS users and 30 matched controls. Both groups were scanned using a volumetric three-dimensional fast field echo sequence and a gradient-echo echo-planar imaging sequence. Impulsivity traits of both groups were evaluated with the Barratt Impulsiveness Scale 11 (BIS 11). Voxel-based morphometry was used to characterize gray matter (GM) deficits in CCS users. The clinical significance of regional volume reduction was investigated by evaluating its association with impulsivity in CCS users and with alterations in resting state functional connectivity when brain regions with GM volume reduction were used as seed areas. RESULTS: Significantly decreased GM volume was observed in CCS users in bilateral ventral medial prefrontal cortex (vmPFC) which was related to greater impulsivity in CCS users. Significantly decreased integration was found in CCS users between the vmPFC and the default mode network. Also, significantly enhanced functional connectivity was found between the vmPFC and the right insula, and the right dorsal lateral PFC. Negative correlation was observed between BIS total scores, scores for attentional impulsivity and vmPFC-inferior parietal lobe connectivity in CCS users. CONCLUSIONS: The findings revealed volume loss and aberrant functional organization in vmPFC among CCS users. In addition, the decreased vmPFCGM volume and attenuated functional connectivity of the vmPFC-inferior parietal lobe network were associated with clinical higher impulsivity trait in CCS users. Crown
RCT Entities:
OBJECTIVE: To characterize the association between clinical symptoms and anatomical and functional cerebral deficits in codeine-containing cough syrups (CCS) users using voxel-based morphometry and resting state functional connectivity analysis. METHODS:Participants were 30 CCS users and 30 matched controls. Both groups were scanned using a volumetric three-dimensional fast field echo sequence and a gradient-echo echo-planar imaging sequence. Impulsivity traits of both groups were evaluated with the Barratt Impulsiveness Scale 11 (BIS 11). Voxel-based morphometry was used to characterize gray matter (GM) deficits in CCS users. The clinical significance of regional volume reduction was investigated by evaluating its association with impulsivity in CCS users and with alterations in resting state functional connectivity when brain regions with GM volume reduction were used as seed areas. RESULTS: Significantly decreased GM volume was observed in CCS users in bilateral ventral medial prefrontal cortex (vmPFC) which was related to greater impulsivity in CCS users. Significantly decreased integration was found in CCS users between the vmPFC and the default mode network. Also, significantly enhanced functional connectivity was found between the vmPFC and the right insula, and the right dorsal lateral PFC. Negative correlation was observed between BIS total scores, scores for attentional impulsivity and vmPFC-inferior parietal lobe connectivity in CCS users. CONCLUSIONS: The findings revealed volume loss and aberrant functional organization in vmPFC among CCS users. In addition, the decreased vmPFC GM volume and attenuated functional connectivity of the vmPFC-inferior parietal lobe network were associated with clinical higher impulsivity trait in CCS users. Crown
Authors: Patrick A McConnell; Eric L Garland; Jon-Kar Zubieta; Roger Newman-Norlund; Shannon Powers; Brett Froeliger Journal: Addict Biol Date: 2019-04-04 Impact factor: 4.280
Authors: Christin Scholz; Hang-Yee Chan; Russell A Poldrack; Denise T D de Ridder; Ale Smidts; Laura Nynke van der Laan Journal: Hum Brain Mapp Date: 2022-09-09 Impact factor: 5.399
Authors: Marc L Copersino; Jenessa S Price; Katherine H Frost; Gordana D Vitaliano; Blaise deB Frederick; Scott E Lukas; Roger D Weiss; Amy C Janes Journal: J Neuropsychiatry Clin Neurosci Date: 2016-01-21 Impact factor: 2.198