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Literature DB >> 24286381

Replacing the thorough QT study: reflections of a baby in the bath water.

Robert B Kleiman¹, Rashmi R Shah, Joel Morganroth.

Abstract

Entities: Chemical

Mesh：

Year: 2014 PMID： 24286381 PMCID： PMC4137815 DOI： 10.1111/bcp.12296

Source DB: PubMed Journal: Br J Clin Pharmacol ISSN： 0306-5251 Impact factor: 4.335

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29 in total

1. The cost-effectiveness of drug regulation: the example of thorough QT/QTc studies.

Authors: J C Bouvy; M A Koopmanschap; R R Shah; H Schellekens
Journal: Clin Pharmacol Ther Date: 2011-12-28 Impact factor: 6.875

2. Modulation of the late sodium current by ATX-II and ranolazine affects the reverse use-dependence and proarrhythmic liability of IKr blockade.

Authors: Shaobin Jia; Jiangfan Lian; Donglin Guo; Xiaolin Xue; Chinmay Patel; Lin Yang; Zuyi Yuan; Aiqun Ma; Gan-Xin Yan
Journal: Br J Pharmacol Date: 2011-09 Impact factor: 8.739

Review 3. Early investigation of QTc liability: the role of multiple ascending dose (MAD) study.

Authors: Rashmi R Shah; Joel Morganroth
Journal: Drug Saf Date: 2012-09-01 Impact factor: 5.606

Review 4. Dealing with global safety issues : was the response to QT-liability of non-cardiac drugs well coordinated?

Authors: Norman Stockbridge; Joel Morganroth; Rashmi R Shah; Christine Garnett
Journal: Drug Saf Date: 2013-03 Impact factor: 5.606

Review 5. Cardiovascular safety of tyrosine kinase inhibitors: with a special focus on cardiac repolarisation (QT interval).

Authors: Rashmi R Shah; Joel Morganroth; Devron R Shah
Journal: Drug Saf Date: 2013-05 Impact factor: 5.606

6. Transmural dispersion of repolarization as a preclinical marker of drug-induced proarrhythmia.

Authors: Tamer H Said; Lance D Wilson; Darwin Jeyaraj; Anthony A Fossa; David S Rosenbaum
Journal: J Cardiovasc Pharmacol Date: 2012-08 Impact factor: 3.105

7. Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk.

Authors: Gary R Mirams; Yi Cui; Anna Sher; Martin Fink; Jonathan Cooper; Bronagh M Heath; Nick C McMahon; David J Gavaghan; Denis Noble
Journal: Cardiovasc Res Date: 2011-02-07 Impact factor: 10.787

Review 8. Application of cardiac electrophysiology simulations to pro-arrhythmic safety testing.

Authors: Gary R Mirams; Mark R Davies; Yi Cui; Peter Kohl; Denis Noble
Journal: Br J Pharmacol Date: 2012-11 Impact factor: 8.739

9. Computational assessment of drug-induced effects on the electrocardiogram: from ion channel to body surface potentials.

Authors: Nejib Zemzemi; Miguel O Bernabeu; Javier Saiz; Jonathan Cooper; Pras Pathmanathan; Gary R Mirams; Joe Pitt-Francis; Blanca Rodriguez
Journal: Br J Pharmacol Date: 2013-02 Impact factor: 8.739

10. Evaluation of an in silico cardiac safety assay: using ion channel screening data to predict QT interval changes in the rabbit ventricular wedge.

Authors: Kylie A Beattie; Chris Luscombe; Geoff Williams; Jordi Munoz-Muriedas; David J Gavaghan; Yi Cui; Gary R Mirams
Journal: J Pharmacol Toxicol Methods Date: 2013-04-25 Impact factor: 1.950

4 in total

1. Balancing the Need for Personalization of QT Correction and Generalization of Study Results: Going Beyond Thorough QT Studies.

Authors: Igor Diemberger; Emanuel Raschi; Gianluca Trifirò
Journal: Clin Drug Investig Date: 2017-10 Impact factor: 2.859