Literature DB >> 24285460

The biological role of carnosine and its possible applications in medicine.

Sandra Budzeń1, Joanna Rymaszewska.   

Abstract

The article reviews current literature on the biological role of carnosine, its properties and use as a supplement in periods of intense physical activity. Studies carried out on laboratory animals and humans have shown that carnosine can have a beneficial influence on the organism. Carnosine is found naturally mainly in the skeletal muscles, central nervous system, olfactory neurons and in the lens of the eye in some vertebrates, including humans. Due to its antioxidant, protective, chelating, anti-glycation activity, this dipeptide can be used to prevent and treat diseases such as diabetes, neurodegenerative diseases, diseases of the sense organs and cancers. It may also cure or alleviate many other disorders thanks to its wide spectrum of activity. Carnosine is already used by athletes to achieve better results, due to its buffering feature, which contributes to the maintenance of the acid-base balance in the muscles. Future studies on the influence of carnosine on the human organism may lead to the therapeutic use of this dipeptide for many diseases, in addition to improving both amateur and professional athletes' results.

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Year:  2013        PMID: 24285460

Source DB:  PubMed          Journal:  Adv Clin Exp Med        ISSN: 1899-5276            Impact factor:   1.727


  13 in total

1.  Neuroprotective effect of carnosine in the olfactory bulb after vanadium inhalation in a mouse model.

Authors:  Laura Colín-Barenque; Patricia Bizarro-Nevares; Adriana González Villalva; Jose Pedraza-Chaverri; Omar Noel Medina-Campos; Ruben Jimenez-Martínez; Daniela S Rodríguez-Rangel; Stefanie Reséndiz; Teresa I Fortoul
Journal:  Int J Exp Pathol       Date:  2018-09-09       Impact factor: 1.925

Review 2.  The management of cognitive impairment in bipolar disorder: current status and perspectives.

Authors:  Marsal Sanches; Isabelle E Bauer; Juan F Galvez; Giovana B Zunta-Soares; Jair C Soares
Journal:  Am J Ther       Date:  2015 Nov-Dec       Impact factor: 2.688

3.  Carnosine modulates nitric oxide in stimulated murine RAW 264.7 macrophages.

Authors:  Giuseppe Caruso; Claudia G Fresta; Francisco Martinez-Becerra; Lopalco Antonio; Ryan T Johnson; Richard P S de Campos; Joseph M Siegel; Manjula B Wijesinghe; Giuseppe Lazzarino; Susan M Lunte
Journal:  Mol Cell Biochem       Date:  2017-03-13       Impact factor: 3.396

4.  Carnosine attenuates early brain injury through its antioxidative and anti-apoptotic effects in a rat experimental subarachnoid hemorrhage model.

Authors:  Zong-yong Zhang; Bao-liang Sun; Ming-feng Yang; Da-wei Li; Jie Fang; Shuai Zhang
Journal:  Cell Mol Neurobiol       Date:  2014-09-02       Impact factor: 5.046

5.  Voluntary wheel running, but not a diet containing (-)-epigallocatechin-3-gallate and β-alanine, improves learning, memory and hippocampal neurogenesis in aged mice.

Authors:  Trisha E Gibbons; Brandt D Pence; Geraldine Petr; Jessica M Ossyra; Houston C Mach; Tushar K Bhattacharya; Samuel Perez; Stephen A Martin; Robert H McCusker; Keith W Kelley; Justin S Rhodes; Rodney W Johnson; Jeffrey A Woods
Journal:  Behav Brain Res       Date:  2014-07-05       Impact factor: 3.332

6.  Monitoring carnosine uptake by RAW 264.7 macrophage cells using microchip electrophoresis with fluorescence detection.

Authors:  Claudia G Fresta; Michael L Hogard; Giuseppe Caruso; Elton E Melo Costa; Giuseppe Lazzarino; Susan M Lunte
Journal:  Anal Methods       Date:  2016-12-14       Impact factor: 2.896

7.  Intrinsic carnosine metabolism in the human kidney.

Authors:  Verena Peters; Celine Q F Klessens; Hans J Baelde; Benjamin Singler; Kimberley A M Veraar; Ana Zutinic; Jakub Drozak; Johannes Zschocke; Claus P Schmitt; Emile de Heer
Journal:  Amino Acids       Date:  2015-07-24       Impact factor: 3.520

8.  Carnosine inhibits the proliferation of human gastric cancer SGC-7901 cells through both of the mitochondrial respiration and glycolysis pathways.

Authors:  Yao Shen; Jianbo Yang; Juan Li; Xiaojie Shi; Li Ouyang; Yueyang Tian; Jianxin Lu
Journal:  PLoS One       Date:  2014-08-12       Impact factor: 3.240

9.  On the use of carnosine and antioxidants: A letter from Russia.

Authors:  Sergei V Jargin
Journal:  J Intercult Ethnopharmacol       Date:  2016-04-21

Review 10.  Characteristics of Selected Antioxidative and Bioactive Compounds in Meat and Animal Origin Products.

Authors:  Bartosz Kulczyński; Andrzej Sidor; Anna Gramza-Michałowska
Journal:  Antioxidants (Basel)       Date:  2019-08-22
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