BACKGROUND: It remains to be elucidated whether brain activity is altered in takotsubo cardiomyopathy. METHODS AND RESULTS: We measured cerebral blood flow (CBF) in 3 consecutive patients with takotsubo cardiomyopathy using (99m)Tc ethyl cysteinate dimmer single photon-emission computed tomography (SPECT) in the acute and chronic phases. In all patients, CBF was significantly increased in the hippocampus, brainstem and basal ganglia and significantly decreased in the prefrontal cortex in the acute phase, which changes subsided in the chronic phase with full recovery of cardiac wall motion. CONCLUSIONS: These results provide the first direct evidence for brain activation in takotsubo cardiomyopathy.
BACKGROUND: It remains to be elucidated whether brain activity is altered in takotsubo cardiomyopathy. METHODS AND RESULTS: We measured cerebral blood flow (CBF) in 3 consecutive patients with takotsubo cardiomyopathy using (99m)Tc ethyl cysteinate dimmer single photon-emission computed tomography (SPECT) in the acute and chronic phases. In all patients, CBF was significantly increased in the hippocampus, brainstem and basal ganglia and significantly decreased in the prefrontal cortex in the acute phase, which changes subsided in the chronic phase with full recovery of cardiac wall motion. CONCLUSIONS: These results provide the first direct evidence for brain activation in takotsubo cardiomyopathy.
Authors: Horacio Medina de Chazal; Marco Giuseppe Del Buono; Lori Keyser-Marcus; Liangsuo Ma; F Gerard Moeller; Daniel Berrocal; Antonio Abbate Journal: J Am Coll Cardiol Date: 2018-10-16 Impact factor: 24.094
Authors: Azar Radfar; Shady Abohashem; Michael T Osborne; Ying Wang; Tawseef Dar; Malek Z O Hassan; Ahmed Ghoneem; Nicki Naddaf; Tomas Patrich; Taimur Abbasi; Hadil Zureigat; James Jaffer; Parastou Ghazi; James A Scott; Lisa M Shin; Roger K Pitman; Tomas G Neilan; Malissa J Wood; Ahmed Tawakol Journal: Eur Heart J Date: 2021-05-14 Impact factor: 35.855
Authors: Arash Nayeri; Eric Rafla-Yuan; Srikanth Krishnan; Boback Ziaeian; Martin Cadeiras; John A McPherson; Quinn S Wells Journal: Psychosomatics Date: 2018-02-02 Impact factor: 2.386