Xiangyu Chen1, Enhua Xiao, Dianshuang Shu, Chengzhi Yang, Bin Liang, Zhong He, Dujun Bian. 1. aDepartment of Radiology, Second Xiangya Hospital, Central South University, Changsha, Hunan bDepartment of Radiology, Huaqiao Hospital, Jinan University, Guangzhou, Guangdong cDepartment of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubai, People's Republic of China.
Abstract
PURPOSE: To compare the characteristics of magnetic resonance perfusion-weighted imaging (MRPWI) scans before and after transcatheter arterial chemoembolization (TACE) treatment of hepatocellular carcinoma (HCC) and to apply MRPWI in evaluating the therapeutic effect of TACE and prognosis of HCC. MATERIALS AND METHODS: Thirty-five patients with HCC undergoing their first TACE treatment were enrolled in this study. T2WI, T1WI, and PWI of MRI were performed 24-48 h before TACE and 48-168 h after TACE. Perfusion parameters calculated with the maximum slope were used to create a time-signal intensity curve (TSC). The efficacy of TACE treatment in HCC was evaluated by examining the hemodynamic changes in TSC caused by TACE treatment. RESULTS: TSC before TACE showed a pattern of a quick decrease and a slow increase in the tumor region of interest in 34 patients with HCC, whereas the TSC for normal liver tissues showed a pattern of slow decrease and slow increase. After TACE, the fluctuating range of TSC was significantly reduced in 31 patients, slightly reduced in three, and did not change significantly in one. The 3-year survival rate was 28.6%. CONCLUSION: MRPWI of the liver does not only show the anatomy of HCC lesions but also reflects hemodynamic changes of HCC before and after TACE to a certain extent. It is very useful for clinical evaluation of the efficacy of TACE for HCC.
PURPOSE: To compare the characteristics of magnetic resonance perfusion-weighted imaging (MRPWI) scans before and after transcatheter arterial chemoembolization (TACE) treatment of hepatocellular carcinoma (HCC) and to apply MRPWI in evaluating the therapeutic effect of TACE and prognosis of HCC. MATERIALS AND METHODS: Thirty-five patients with HCC undergoing their first TACE treatment were enrolled in this study. T2WI, T1WI, and PWI of MRI were performed 24-48 h before TACE and 48-168 h after TACE. Perfusion parameters calculated with the maximum slope were used to create a time-signal intensity curve (TSC). The efficacy of TACE treatment in HCC was evaluated by examining the hemodynamic changes in TSC caused by TACE treatment. RESULTS: TSC before TACE showed a pattern of a quick decrease and a slow increase in the tumor region of interest in 34 patients with HCC, whereas the TSC for normal liver tissues showed a pattern of slow decrease and slow increase. After TACE, the fluctuating range of TSC was significantly reduced in 31 patients, slightly reduced in three, and did not change significantly in one. The 3-year survival rate was 28.6%. CONCLUSION: MRPWI of the liver does not only show the anatomy of HCC lesions but also reflects hemodynamic changes of HCC before and after TACE to a certain extent. It is very useful for clinical evaluation of the efficacy of TACE for HCC.
Authors: Roland Syha; Gerd Grözinger; Ulrich Grosse; Michael Maurer; Lars Zender; Marius Horger; Konstantin Nikolaou; Dominik Ketelsen Journal: Cancer Imaging Date: 2015-12-29 Impact factor: 3.909
Authors: Roland Syha; Sergios Gatidis; Gerd Grözinger; Ulrich Grosse; Michael Maurer; Lars Zender; Marius Horger; Konstantin Nikolaou; Dominik Ketelsen Journal: Cancer Imaging Date: 2016-09-21 Impact factor: 3.909