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Literature DB >> 24282707

Impact of Next-Generation Sequencing (NGS) technology on cardiovascular disease research.

Fengping Xu¹, Qin Wang, Fangfang Zhang, Yinling Zhu, Qingquan Gu, Liping Wu, Lin Yang, Xu Yang.
1. BGI-Shenzhen, Shenzhen, China.

Abstract

In recent years, hundreds of gene loci associated with multiple cardiovascular pathologies and traits have been identified through high-throughput Next-Generation Sequencing (NGS) technology. Due to the increasing efficiency and decreasing cost of NGS, rapid progresses anticipated in the field of CVD research. This review summarizes the main strategies of CV research with NGS at the level of genomics, transcriptomics, epigenetics, and proteomics.

Entities: Disease

Keywords: Cardiovascular disease; Next-Generation Sequencing; epigenetics; genomics; proteomics

Year: 2012 PMID： 24282707 PMCID： PMC3839151 DOI： 10.3978/j.issn.2223-3652.2012.06.01

Source DB: PubMed Journal: Cardiovasc Diagn Ther ISSN： 2223-3652

12 in total

Review 1. Genomics of cardiovascular disease.

Authors: Christopher J O'Donnell; Elizabeth G Nabel
Journal: N Engl J Med Date: 2011-12-01 Impact factor: 91.245

Review 2. Annotating individual human genomes.

Authors: Ali Torkamani; Ashley A Scott-Van Zeeland; Eric J Topol; Nicholas J Schork
Journal: Genomics Date: 2011-08-02 Impact factor: 5.736

Review 3. Protein biomarker discovery and validation: the long and uncertain path to clinical utility.

Authors: Nader Rifai; Michael A Gillette; Steven A Carr
Journal: Nat Biotechnol Date: 2006-08 Impact factor: 54.908

Review 4. Next steps in cardiovascular disease genomic research--sequencing, epigenetics, and transcriptomics.

Authors: Renate B Schnabel; Andrea Baccarelli; Honghuang Lin; Patrick T Ellinor; Emelia J Benjamin
Journal: Clin Chem Date: 2011-11-18 Impact factor: 8.327

Review 5. Genomewide association studies in cardiovascular disease--an update 2011.

Authors: Tanja Zeller; Stefan Blankenberg; Patrick Diemert
Journal: Clin Chem Date: 2011-11-28 Impact factor: 8.327

6. A pipeline that integrates the discovery and verification of plasma protein biomarkers reveals candidate markers for cardiovascular disease.

Authors: Terri A Addona; Xu Shi; Hasmik Keshishian; D R Mani; Michael Burgess; Michael A Gillette; Karl R Clauser; Dongxiao Shen; Gregory D Lewis; Laurie A Farrell; Michael A Fifer; Marc S Sabatine; Robert E Gerszten; Steven A Carr
Journal: Nat Biotechnol Date: 2011-06-19 Impact factor: 54.908

Review 2. Application of Single-Nucleotide Polymorphism-Related Risk Estimates in Identification of Increased Genetic Susceptibility to Cardiovascular Diseases: A Literature Review.

Authors: Szilvia Fiatal; Róza Ádány
Journal: Front Public Health Date: 2018-01-31

2 in total

Impact of Next-Generation Sequencing (NGS) technology on cardiovascular disease research.

Review 1. Genomics of cardiovascular disease.

Review 2. Annotating individual human genomes.

Review 3. Protein biomarker discovery and validation: the long and uncertain path to clinical utility.

Review 4. Next steps in cardiovascular disease genomic research--sequencing, epigenetics, and transcriptomics.

Review 5. Genomewide association studies in cardiovascular disease--an update 2011.

6. A pipeline that integrates the discovery and verification of plasma protein biomarkers reveals candidate markers for cardiovascular disease.

Review 7. Proteomics and heart disease: identifying biomarkers of clinical utility.

8. 10-years experience with the Athero-Express study.

Review 9. The role of proteomics in clinical cardiovascular biomarker discovery.

10. 9p21 DNA variants associated with coronary artery disease impair interferon-γ signalling response.

1. 'Longitudinal' topics in Cardiovascular Diagnosis and Therapy (CDT).

Review 2. Application of Single-Nucleotide Polymorphism-Related Risk Estimates in Identification of Increased Genetic Susceptibility to Cardiovascular Diseases: A Literature Review.