Literature DB >> 24282697

Angiotensin II type-2 receptor-specific effects on the cardiovascular system.

Ying Li1, Xiao-Hui Li, Hong Yuan.   

Abstract

The renin-angiotensin system (RAS) is intricately involved in cardiovascular homeostasis. It is well known that angiotensin II, the key effector in RAS, contributes to a range of cardiovascular pathologies and diseases via angiotensin II type-1 receptor (AT1R) activation. However, the role of angiotensin II type-2 receptor (AT2R) regulation is less well understood. Recent studies describe the role of the AT2R on cardiovascular function in normal and pathologic conditions. The data describe an important role of AT2R in blood pressure regulation, cardiac hypertrophy and fibrosis, myocardial infarction and vascular homeostasis.

Entities:  

Keywords:  AT2 receptor; Rennin-angiotensin system; cardiovascular disea

Year:  2012        PMID： 24282697      PMCID： PMC3839167          DOI： 10.3978/j.issn.2223-3652.2012.02.02

Source DB:  PubMed          Journal:  Cardiovasc Diagn Ther        ISSN： 2223-3652


  51 in total

1.  The subtype-2 (AT2) angiotensin receptor regulates renal cyclic guanosine 3', 5'-monophosphate and AT1 receptor-mediated prostaglandin E2 production in conscious rats.

Authors:  H M Siragy; R M Carey
Journal:  J Clin Invest       Date:  1996-04-15       Impact factor: 14.808

2.  Angiotensin II type 2 receptors contribute to vascular responses in spontaneously hypertensive rats treated with angiotensin II type 1 receptor antagonists.

Authors:  Francesco Cosentino; Carmine Savoia; Paola De Paolis; Pietro Francia; Alessandro Russo; Angelo Maffei; Vanessa Venturelli; Marzia Schiavoni; Giuseppe Lembo; Massimo Volpe
Journal:  Am J Hypertens       Date:  2005-04       Impact factor: 2.689

3.  Effects of angiotensin metabolites in the coronary vascular bed of the spontaneously hypertensive rat: loss of angiotensin II type 2 receptor-mediated vasodilation.

Authors:  Els Moltzer; Anna V A Verkuil; Richard van Veghel; A H Jan Danser; Joep H M van Esch
Journal:  Hypertension       Date:  2009-12-21       Impact factor: 10.190

4.  Angiotensin AT2 receptor contributes to cardiovascular remodelling of aged rats during chronic AT1 receptor blockade.

Authors:  Emma S Jones; M Jane Black; Robert E Widdop
Journal:  J Mol Cell Cardiol       Date:  2004-11       Impact factor: 5.000

5.  Stimulation of angiotensin AT2 receptors by the non-peptide agonist, Compound 21, evokes vasodepressor effects in conscious spontaneously hypertensive rats.

Authors:  S Bosnyak; I K Welungoda; A Hallberg; M Alterman; R E Widdop; E S Jones
Journal:  Br J Pharmacol       Date:  2010-01-28       Impact factor: 8.739

6.  Angiotensin II type 2 receptor gene transfer elicits cardioprotective effects in an angiotensin II infusion rat model of hypertension.

Authors:  Beverly L Falcón; Jillian M Stewart; Erick Bourassa; Michael J Katovich; Glenn Walter; Robert C Speth; Colin Sumners; Mohan K Raizada
Journal:  Physiol Genomics       Date:  2004-09-21       Impact factor: 3.107

7.  Role of type 1 and type 2 angiotensin receptors in angiotensin II-induced cardiomyocyte hypertrophy.

Authors:  G W Booz; K M Baker
Journal:  Hypertension       Date:  1996-10       Impact factor: 10.190

8.  Angiotensin II type 2 receptor overexpression preserves left ventricular function after myocardial infarction.

Authors:  Zequan Yang; Christina M Bove; Brent A French; Frederick H Epstein; Stuart S Berr; Joseph M DiMaria; Jennifer J Gibson; Robert M Carey; Christopher M Kramer
Journal:  Circulation       Date:  2002-07-02       Impact factor: 29.690

9.  Human type 2 angiotensin II receptor gene: cloned, mapped to the X chromosome, and its mRNA is expressed in the human lung.

Authors:  G Koike; M Horiuchi; T Yamada; C Szpirer; H J Jacob; V J Dzau
Journal:  Biochem Biophys Res Commun       Date:  1994-09-30       Impact factor: 3.575

10.  Pressure overload-induced hypertrophy in transgenic mice selectively overexpressing AT2 receptors in ventricular myocytes.

Authors:  Xinhua Yan; Adam J T Schuldt; Robert L Price; Ivo Amende; Fen-Fen Liu; Katashi Okoshi; Kalon K L Ho; Adèle J Pope; Thomas K Borg; Beverly H Lorell; James P Morgan
Journal:  Am J Physiol Heart Circ Physiol       Date:  2008-01-04       Impact factor: 4.733
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  22 in total

1.  Communication of novel concepts.

Authors:  Paul Schoenhagen
Journal:  Cardiovasc Diagn Ther       Date:  2012-03

2.  The angiotensin II type 2 receptor agonist Compound 21 is protective in experimental diabetes-associated atherosclerosis.

Authors:  Bryna S M Chow; Christine Koulis; Pooja Krishnaswamy; Ulrike M Steckelings; Thomas Unger; Mark E Cooper; Karin A Jandeleit-Dahm; Terri J Allen
Journal:  Diabetologia       Date:  2016-05-11       Impact factor: 10.122

3.  Maternal titanium dioxide nanomaterial inhalation exposure compromises placental hemodynamics.

Authors:  Alaeddin B Abukabda; Elizabeth C Bowdridge; Carroll R McBride; Thomas P Batchelor; William T Goldsmith; Krista L Garner; Sherri Friend; Timothy R Nurkiewicz
Journal:  Toxicol Appl Pharmacol       Date:  2019-02-01       Impact factor: 4.219

Review 4.  AT2 receptor activities and pathophysiological implications.

Authors:  Luis C Matavelli; Helmy M Siragy
Journal:  J Cardiovasc Pharmacol       Date:  2015-03       Impact factor: 3.105

5.  Maternal Engineered Nanomaterial Inhalation During Gestation Disrupts Vascular Kisspeptin Reactivity.

Authors:  Elizabeth C Bowdridge; Alaeddin B Abukabda; Kevin J Engles; Carroll R McBride; Thomas P Batchelor; William T Goldsmith; Krista L Garner; Sherri Friend; Timothy R Nurkiewicz
Journal:  Toxicol Sci       Date:  2019-06-01       Impact factor: 4.849

6.  Angiotensin type 1 receptor mediates renal production and conversion of prostaglandins E2 to F2α in conscious diabetic rats.

Authors:  Peter M Abadir; Helmy M Siragy
Journal:  J Renin Angiotensin Aldosterone Syst       Date:  2015-07-20       Impact factor: 1.636

7.  Hypotensive and sympathoinhibitory responses to selective central AT2 receptor stimulation in spontaneously hypertensive rats.

Authors:  Sofie Brouwers; Ilse Smolders; Richard D Wainford; Alain G Dupont
Journal:  Clin Sci (Lond)       Date:  2015-07       Impact factor: 6.124

Review 8.  Structural perspectives on the mechanism of signal activation, ligand selectivity and allosteric modulation in angiotensin receptors: IUPHAR Review 34.

Authors:  Khuraijam Dhanachandra Singh; Sadashiva S Karnik
Journal:  Br J Pharmacol       Date:  2022-04-23       Impact factor: 9.473

Review 9.  Calcific Aortic Valve Disease: Part 2-Morphomechanical Abnormalities, Gene Reexpression, and Gender Effects on Ventricular Hypertrophy and Its Reversibility.

Authors:  Ares Pasipoularides
Journal:  J Cardiovasc Transl Res       Date:  2016-05-16       Impact factor: 4.132

10.  Critical role of angiotensin II type 2 receptors in the control of mitochondrial and cardiac function in angiotensin II-preconditioned rat hearts.

Authors:  Rebeca E Nuñez; Sabzali Javadov; Nelson Escobales
Journal:  Pflugers Arch       Date:  2018-05-10       Impact factor: 3.657
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