| Literature DB >> 24281890 |
Norberto Garcia-Cairasco1, Miguel Moyses-Neto, Flavio Del Vecchio, José A C Oliveira, Francisco L dos Santos, Olagide W Castro, Gabriel M Arisi, Márcio Dantas, Ruither O G Carolino, Joaquim Coutinho-Netto, Andre L A Dagostin, Marcelo C A Rodrigues, Ricardo M Leão, Samir A P Quintiliano, Luiz F Silva, Leonardo Gobbo-Neto, Norberto P Lopes.
Abstract
Caramboxin: Patients suffering from chronic kidney disease are frequently intoxicated after ingesting star fruit. The main symptoms of this intoxication are named in the picture. Bioguided chemical procedures resulted in the discovery of caramboxin, which is a phenylalanine-like molecule that is responsible for intoxication. Functional experiments in vivo and in vitro point towards the glutamatergic ionotropic molecular actions of caramboxin, which explains its convulsant and neurodegenerative properties.Entities:
Keywords: natural products; neurological agents; neurotoxins; receptors; star fruit
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Year: 2013 PMID： 24281890 DOI： 10.1002/anie.201305382
Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336