BACKGROUND: Primary anaplastic large-cell lymphoma (ALCL) occurring in women with breast implants is very rare. It is usually described as tumor cells infiltrating the periprosthetic capsule. These are most often revealed by a periprosthetic recurrent isolated effusion (seroma cavity), occurring late after implantation of the prosthesis. ALCL is more rarely a tumor or periprosthetic capsular contracture. CASE: We report a 66-year-old woman, initially diagnosed by cytological examination of breast effusion, in whom ALCL appeared two and a half months after the removal of a ruptured implant. Repeated biopsies of the periprosthetic capsule performed in parallel showed fibrous tissue, without tumor proliferation. Only meticulous histological examination of the total capsulectomy identified tumor cells as a thin and discontinuous layer along the inner surface of the capsule without capsular invasion. CONCLUSION: Awareness of the histological pattern of this new clinical entity is important. A total capsulectomy with a good sampling for microscopic examination should be conducted for any suspicion of breast implant-associated ALCL. Cytology-histology correlation is essential.
BACKGROUND: Primary anaplastic large-cell lymphoma (ALCL) occurring in women with breast implants is very rare. It is usually described as tumor cells infiltrating the periprosthetic capsule. These are most often revealed by a periprosthetic recurrent isolated effusion (seroma cavity), occurring late after implantation of the prosthesis. ALCL is more rarely a tumor or periprosthetic capsular contracture. CASE: We report a 66-year-old woman, initially diagnosed by cytological examination of breast effusion, in whom ALCL appeared two and a half months after the removal of a ruptured implant. Repeated biopsies of the periprosthetic capsule performed in parallel showed fibrous tissue, without tumor proliferation. Only meticulous histological examination of the total capsulectomy identified tumor cells as a thin and discontinuous layer along the inner surface of the capsule without capsular invasion. CONCLUSION: Awareness of the histological pattern of this new clinical entity is important. A total capsulectomy with a good sampling for microscopic examination should be conducted for any suspicion of breast implant-associated ALCL. Cytology-histology correlation is essential.
Authors: Tessa L St Cyr; Barbara A Pockaj; Donald W Northfelt; Fiona E Craig; Mark W Clemens; Raman C Mahabir Journal: Plast Surg (Oakv) Date: 2020-05-21 Impact factor: 0.947
Authors: Maria C Ferrufino-Schmidt; L Jeffrey Medeiros; Hui Liu; Mark W Clemens; Kelly K Hunt; Camille Laurent; Julian Lofts; Mitual B Amin; Siaw Ming Chai; Angela Morine; Arianna Di Napoli; Ahmet Dogan; Vinita Parkash; Govind Bhagat; Denise Tritz; Andres E Quesada; Sergio Pina-Oviedo; Qinlong Hu; Francisco J Garcia-Gomez; Juan Jose Borrero; Pedro Horna; Beenu Thakral; Marina Narbaitz; R Condon Hughes; Li-Jun Yang; Jonathan R Fromm; David Wu; Da Zhang; Aliyah R Sohani; John Hunt; Indira U Vadlamani; Elizabeth A Morgan; Judith A Ferry; Reka Szigeti; Juan C Tardio; Rosario Granados; Susanne Dertinger; Felix A Offner; Andreas Pircher; Jeff Hosry; Ken H Young; Roberto N Miranda Journal: Am J Surg Pathol Date: 2018-03 Impact factor: 6.394
Authors: Andrés E Quesada; L Jeffrey Medeiros; Mark W Clemens; Maria C Ferrufino-Schmidt; Sergio Pina-Oviedo; Roberto N Miranda Journal: Mod Pathol Date: 2018-09-11 Impact factor: 7.842