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Literature DB >> 24279334

Zebrafish: a model vertebrate suitable for the analysis of human genetic disorders.

Abstract

Zebrafish is a popular model vertebrate because of its conservation of a significant number of morphological and physiological processes in vertebrate organogenesis. A number of zebrafish mutants isolated from chemical mutagenesis screens exhibit characterized morphological defects that often resemble the symptoms of human genetic disorders. Recent innovations in genome-editing technologies, such as transcription activator-like effector nucleases (TALEN) and the clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 system, enable us to investigate the loss-of-function phenotypes of developmentally regulated genes in zebrafish. This review highlights recent advances in reverse genetic technologies for zebrafish and presents possible applications of zebrafish for the study of human genetic disorders.

Entities: Disease Species

Keywords: clustered regularly interspaced short palindromic repeats/Cas9; genome editing; model organism; transcription activator-like effector nuclease; zebrafish

Mesh：

Year: 2014 PMID： 24279334 DOI： 10.1111/cga.12040

Source DB: PubMed Journal: Congenit Anom (Kyoto) ISSN： 0914-3505 Impact factor: 1.409

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Cited

10 in total

1. A method for CRISPR/Cas9 mutation of genes in fathead minnow (Pimephales promelas).

Authors: Jennifer A Maki; Jenna E Cavallin; Kevin G Lott; Travis W Saari; Gerald T Ankley; Daniel L Villeneuve
Journal: Aquat Toxicol Date: 2020-03-02 Impact factor: 4.964

2. An efficient platform for generating somatic point mutations with germline transmission in the zebrafish by CRISPR/Cas9-mediated gene editing.

Authors: Yibo Zhang; Zhiwei Zhang; Wei Ge
Journal: J Biol Chem Date: 2018-03-02 Impact factor: 5.157

3. Zebrafish have an ethanol-inducible hepatic 4-nitrophenol hydroxylase that is not CYP2E1-like.

Authors: Jessica H Hartman; Jordan S Kozal; Richard T Di Giulio; Joel N Meyer
Journal: Environ Toxicol Pharmacol Date: 2017-07-10 Impact factor: 4.860

4. Wild sex in zebrafish: loss of the natural sex determinant in domesticated strains.

Authors: Catherine A Wilson; Samantha K High; Braedan M McCluskey; Angel Amores; Yi-lin Yan; Tom A Titus; Jennifer L Anderson; Peter Batzel; Michael J Carvan; Manfred Schartl; John H Postlethwait
Journal: Genetics Date: 2014-09-18 Impact factor: 4.562

5. Comparative study of herbal plants on the phenolic and flavonoid content, antioxidant activities and toxicity on cells and zebrafish embryo.

Authors: Hassan Fahmi Ismail; Zanariah Hashim; Wong Tet Soon; Nur Syukriah Ab Rahman; Ain Nabihah Zainudin; Fadzilah Adibah Abdul Majid
Journal: J Tradit Complement Med Date: 2017-01-16

Zebrafish: a model vertebrate suitable for the analysis of human genetic disorders.

1. A method for CRISPR/Cas9 mutation of genes in fathead minnow (Pimephales promelas).

2. An efficient platform for generating somatic point mutations with germline transmission in the zebrafish by CRISPR/Cas9-mediated gene editing.

3. Zebrafish have an ethanol-inducible hepatic 4-nitrophenol hydroxylase that is not CYP2E1-like.

4. Wild sex in zebrafish: loss of the natural sex determinant in domesticated strains.

5. Comparative study of herbal plants on the phenolic and flavonoid content, antioxidant activities and toxicity on cells and zebrafish embryo.

6. Modeling Neuronal Diseases in Zebrafish in the Era of CRISPR.

7. CRISPR/Cas9-mediated generation of biallelic F0 anemonefish (Amphiprion ocellaris) mutants.

Review 8. Site-Specific Integration of Exogenous Genes Using Genome Editing Technologies in Zebrafish.

Review 9. Zebrafish as a Model for Drug Screening in Genetic Kidney Diseases.

10. Efficient Production and Identification of CRISPR/Cas9-generated Gene Knockouts in the Model System Danio rerio.