Literature DB >> 2427933

A mechanism for the insertion of complement component C9 into target membranes.

K K Stanley, M Page, A K Campbell, J P Luzio.   

Abstract

Complement component C9 is a globular serum protein which can insert and polymerise in a target membrane to form a large membrane channel. The ability to insert in the membrane is conferred by amphipathetic elements of secondary structure in the central part of the molecule. Towards each end high cysteine domains are found, one of which is homologous to the apoprotein binding domains of the LDL receptor. From the sequence and topological data for C9 we present a model for its structure and insertion into the membrane.

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Year:  1986        PMID： 2427933     DOI： 10.1016/0161-5890(86)90108-2

Source DB:  PubMed          Journal:  Mol Immunol        ISSN： 0161-5890            Impact factor:   4.407


  18 in total

1.  Occurrence of beta-hydroxylated asparagine residues in non-vitamin K-dependent proteins containing epidermal growth factor-like domains.

Authors:  C T Przysiecki; J E Staggers; H G Ramjit; D G Musson; A M Stern; C D Bennett; P A Friedman
Journal:  Proc Natl Acad Sci U S A       Date:  1987-11       Impact factor: 11.205

2.  Characterization of a cDNA encoding a cysteine-rich cell surface protein located in the flagellar pocket of the protozoan Trypanosoma brucei.

Authors:  M G Lee; B E Bihain; D G Russell; R J Deckelbaum; L H Van der Ploeg
Journal:  Mol Cell Biol       Date:  1990-09       Impact factor: 4.272

3.  Mutation of recombinant complement component C9 reveals the significance of the N-terminal region for polymerization.

Authors:  K M Taylor; A R Trimby; A K Campbell
Journal:  Immunology       Date:  1997-05       Impact factor: 7.397

4.  Imaging bioluminescent indicators shows Ca2+ and ATP permeability thresholds in live cells attacked by complement.

Authors:  G B Sala-Newby; K M Taylor; M N Badminton; C M Rembold; A K Campbell
Journal:  Immunology       Date:  1998-04       Impact factor: 7.397

5.  Topology of the membrane-bound form of complement protein C9 probed by glycosylation mapping, anti-peptide antibody binding, and disulfide modification.

Authors:  Véronique Rossi; Yunxia Wang; Alfred F Esser
Journal:  Mol Immunol       Date:  2010-02-12       Impact factor: 4.407

6.  The preparation and characterization of monoclonal antibodies to human complement component C8 and their use in purification of C8 and C8 subunits.

Authors:  A Abraha; B P Morgan; J P Luzio
Journal:  Biochem J       Date:  1988-04-01       Impact factor: 3.857

7.  Cloning, analysis, and expression of murine perforin 1 cDNA, a component of cytolytic T-cell granules with homology to complement component C9.

Authors:  D M Lowrey; T Aebischer; K Olsen; M Lichtenheld; F Rupp; H Hengartner; E R Podack
Journal:  Proc Natl Acad Sci U S A       Date:  1989-01       Impact factor: 11.205

8.  Inhibition of the formation of the complement membrane-attack complex by a monoclonal antibody to the complement component C8 alpha subunit.

Authors:  A Abraha; J P Luzio
Journal:  Biochem J       Date:  1989-12-15       Impact factor: 3.857

9.  Characterization of primary amino acid sequence of human complement control protein factor I from an analysis of cDNA clones.

Authors:  C F Catterall; A Lyons; R B Sim; A J Day; T J Harris
Journal:  Biochem J       Date:  1987-03-15       Impact factor: 3.857

Review 10.  Infectious diseases associated with complement deficiencies.

Authors:  J E Figueroa; P Densen
Journal:  Clin Microbiol Rev       Date:  1991-07       Impact factor: 26.132
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