| Literature DB >> 24279324 |
Wei Wang1, Jia-Tian Lu, Hao-Li Zhang, Zi-Fa Shi, Jing Wen, Xiao-Ping Cao.
Abstract
An efficient formal synthesis of (±)-cycloclavine is achieved in seven steps and 27% overall yield from the known 2-(4-bromo-1-tosyl-1H-indol-3-yl)acetaldehyde. Key features include an iron(III)-catalyzed aza-Cope-Mannich cyclization and an intramolecular Heck reaction or a self-terminating 6-exo-trig aryl radical-alkene cyclization.Entities:
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Year: 2013 PMID： 24279324 DOI： 10.1021/jo4023588
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354