| Literature DB >> 24277735 |
Chiara Fenoglio1, Elisa Ridolfi, Claudia Cantoni, Milena De Riz, Rossana Bonsi, Maria Serpente, Chiara Villa, Anna M Pietroboni, Robert T Naismith, Enrique Alvarez, Becky J Parks, Nereo Bresolin, Anne H Cross, Laura M Piccio, Daniela Galimberti, Elio Scarpini.
Abstract
Emerging evidence underlines the importance of micro(mi)RNAs in the pathogenesis of multiple sclerosis (MS). Free-circulating miRNAs were investigated in serum from MS patients compared to controls. Statistically significant decreased levels of miR-15b, miR-23a and miR-223 were observed in MS patients (p < 0.05). Results were validated and replicated in two further independent MS populations. A direct correlation between miRNA levels and the EDSS score was determined in PPMS (p < 0.007). The generalized trend toward miRNA down-regulation could result in over-expression of target genes involved in disease pathogenesis. Circulating miRNA profiling could thus represent a new avenue to identify easily detectable disease biomarkers.Entities:
Keywords: Multiple sclerosis; biomarkers; demyelination; microRNA; serum
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Year: 2013 PMID： 24277735 DOI： 10.1177/1352458513485654
Source DB: PubMed Journal: Mult Scler ISSN： 1352-4585 Impact factor: 6.312