Literature DB >> 24277363

In vitro Metabolism of Bumetanide.

G Grosa1, F Viola, O Caputo, G Biglino.   

Abstract

A new metabolite of the diuretic drug bumetanide, the 4-[(4'-hydroxy)-phenoxy] analog (7), was identified in incubation mixtures of rat liver microsomes. Phenobarbital and clofibrate pretreatment to induce microsomal enzymes changed the relative amounts of the six metabolites formed. Compound 7was the most prevalent metabolite after clofibrate pretreatment.

Entities:  

Year:  1984        PMID： 24277363     DOI： 10.1023/A:1016302203941

Source DB:  PubMed          Journal:  Pharm Res        ISSN： 0724-8741            Impact factor:   4.200


  9 in total

1.  A relationship between the metabolism of bumetanide and its diuretic activity in the rat.

Authors:  S C Halladay; D E Carter; I G Sipes
Journal:  Drug Metab Dispos       Date:  1978 Jan-Feb       Impact factor: 3.922

2.  Identification of the urinary metabolites of 14C-bumetanide in the rat and their excretion by rats and dogs.

Authors:  S J Kolis; T H Williams; M A Schwartz
Journal:  Drug Metab Dispos       Date:  1976 Mar-Apr       Impact factor: 3.922

3.  Proceedings: Species differences in the diuretic activity and metabolism of bumetanide.

Authors:  M P Magnussen; E Eilertsen
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1974       Impact factor: 3.000

4.  Species differences in the biotransformation of a new antiarrhythmic agent: disopyramide phosphate.

Authors:  A Karim; R E Ranney; S Kraychy
Journal:  J Pharm Sci       Date:  1972-06       Impact factor: 3.534

5.  Studies of the fate of metabolites and analogs of probenecid. The significance of metabolic sites, especially lack of ring hydroxylation.

Authors:  P G Dayton; J M Perel; R F Cunningham; Z H Israili; I M Weiner
Journal:  Drug Metab Dispos       Date:  1973 Nov-Dec       Impact factor: 3.922

6.  Metabolism of bumetanide.

Authors:  M A Schwartz
Journal:  J Clin Pharmacol       Date:  1981 Nov-Dec       Impact factor: 3.126

7.  The metabolic fate of amphetamine in man and other species.

Authors:  L G Dring; R L Smith; R T Williams
Journal:  Biochem J       Date:  1970-02       Impact factor: 3.857

8.  Cytochrome P-450 induction by clofibrate. Purification and properties of a hepatic cytochrome P-450 relatively specific for the 12- and 11-hydroxylation of dodecanoic acid (lauric acid).

Authors:  G G Gibson; T C Orton; P P Tamburini
Journal:  Biochem J       Date:  1982-04-01       Impact factor: 3.857

9.  Aminobenzoic acid diuretics. 2. 4-Substituted-3-amino-5-sulfamylbenzoic acid derivatives.

Authors:  P W Feit
Journal:  J Med Chem       Date:  1971-05       Impact factor: 7.446
  9 in total

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