Literature DB >> 24277220

Synthesis of 8-(3-Carboxy-l-methyl-propylammo)-6-methoxyquinoline: A Newly Characterized Primaquine Metabolite.

J D McChesney1, S Sarangan.   

Abstract

Primaquine (I), a 6-methoxy-8-aminoqumoline derivative used for the treatment of malaria has previously been shown to be metabolized to 8-(3-carboxy-l-methyl-propylamino)-6-methoxyquinoline by both micro-organisms and laboratory rats. Reported herein is the synthesis of this novel metabolite.

Entities:  

Year:  1984        PMID： 24277220     DOI： 10.1023/A:1016311616719

Source DB:  PubMed          Journal:  Pharm Res        ISSN： 0724-8741            Impact factor:   4.200


  5 in total

1.  A metabolite of pamaquine from chickens.

Authors:  E S JOSEPHSON; J GREENBERG; D J TAYLOR; H L BAMI
Journal:  J Pharmacol Exp Ther       Date:  1951-09       Impact factor: 4.030

2.  A metabolic intermediate of pamaquine from chickens.

Authors:  E S JOSEPHSON; D J TAYLOR; J GREENBERG; A P RAY
Journal:  Proc Soc Exp Biol Med       Date:  1951-04

3.  Metabolites of pamaquine in urine.

Authors:  B B BRODIE; S UDENFRIEND
Journal:  Proc Soc Exp Biol Med       Date:  1950-08

Review 4.  Chemotherapy of the drug-resistant malarias.

Authors:  L H Schmidt
Journal:  Annu Rev Microbiol       Date:  1969       Impact factor: 15.500

5.  Primaquine: metabolism by microorganisms and 13C nuclear magnetic resonance assignments.

Authors:  A M Clark; C D Huford; J D McChesney
Journal:  Antimicrob Agents Chemother       Date:  1981-02       Impact factor: 5.191
  5 in total
  2 in total

1.  Differential kinetic profiles and metabolism of primaquine enantiomers by human hepatocytes.

Authors:  Pius S Fasinu; Bharathi Avula; Babu L Tekwani; N P Dhammika Nanayakkara; Yan-Hong Wang; H M T Bandara Herath; James D McChesney; Gregory A Reichard; Sean R Marcsisin; Mahmoud A Elsohly; Shabana I Khan; Ikhlas A Khan; Larry A Walker
Journal:  Malar J       Date:  2016-04-19       Impact factor: 2.979

2.  Metabolism of primaquine in normal human volunteers: investigation of phase I and phase II metabolites from plasma and urine using ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry.

Authors:  Bharathi Avula; Babu L Tekwani; Narayan D Chaurasiya; Pius Fasinu; N P Dhammika Nanayakkara; H M T Bhandara Herath; Yan-Hong Wang; Ji-Yeong Bae; Shabana I Khan; Mahmoud A Elsohly; James D McChesney; Peter A Zimmerman; Ikhlas A Khan; Larry A Walker
Journal:  Malar J       Date:  2018-08-13       Impact factor: 2.979
  2 in total

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