Literature DB >> 24277186

WIN 44,441: A Stereospecific and Long-Acting Narcotic Antagonist.

P L Wood1, C Pilapil, M Thakur, J W Richard.   

Abstract

The opiate antagonist WIN 44,441-3 is a potent, stereospecific antagonist of mu, delta, and kappa opiate receptors. This antagonist activity is of long duration (> 4 h) with no agonist activity being observed. It therefore appears that WIN 44,441-3 will be a useful long-acting opiate antagonist for in vivo studies.

Year:  1984        PMID： 24277186     DOI： 10.1023/A:1016386811268

Source DB:  PubMed          Journal:  Pharm Res        ISSN： 0724-8741            Impact factor:   4.200


  46 in total

1.  Isolation of an endogenous compound from the brain with pharmacological properties similar to morphine.

Authors:  J Hughes
Journal:  Brain Res       Date:  1975-05-02       Impact factor: 3.252

2.  Multiple opiate receptors. Enkephalins and morphine bind to receptors of different specificity.

Authors:  K J Chang; P Cuatrecasas
Journal:  J Biol Chem       Date:  1979-04-25       Impact factor: 5.157

3.  Isolation and structure of an untriakontapeptide with opiate activity from camel pituitary glands.

Authors:  C H Li; D Chung
Journal:  Proc Natl Acad Sci U S A       Date:  1976-04       Impact factor: 11.205

4.  Dynorphin-(1-13), an extraordinarily potent opioid peptide.

Authors:  A Goldstein; S Tachibana; L I Lowney; M Hunkapiller; L Hood
Journal:  Proc Natl Acad Sci U S A       Date:  1979-12       Impact factor: 11.205

5.  Endorphins in psychiatry: an overview and a hypothesis.

Authors:  K Verebey; J Volavka; D Clouet
Journal:  Arch Gen Psychiatry       Date:  1978-07

6.  Mu opiate isoreceptors: differentiation with kappa agonists.

Authors:  P L Wood; J W Richard; M Thakur
Journal:  Life Sci       Date:  1982 Nov 15-22       Impact factor: 5.037

Review 7.  Discriminative stimulus effects of narcotics: evidence for multiple receptor-mediated actions.

Authors:  S Herling; J H Woods
Journal:  Life Sci       Date:  1981-04-06       Impact factor: 5.037

8.  Naloxone reverses the antihypertensive effect of clonidine.

Authors:  C Farsang; G Kunos
Journal:  Br J Pharmacol       Date:  1979-10       Impact factor: 8.739

9.  Interactions between narcotic agonists, partial agonists and antagonists evaluated by schedule-controlled behavior.

Authors:  R A Harris
Journal:  J Pharmacol Exp Ther       Date:  1980-06       Impact factor: 4.030

10.  Naloxone treatment of endotoxin shock: stereospecificity of physiologic and pharmacologic effects in the rat.

Authors:  A I Faden; J W Holaday
Journal:  J Pharmacol Exp Ther       Date:  1980-03       Impact factor: 4.030
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  2 in total

1.  Conformation and electrostatic potential surfaces of opiates: Relationship to µ- and λ-site binding.

Authors:  T P Lybrand; P A Kollman; V C Yu; W Sadée
Journal:  Pharm Res       Date:  1986-08       Impact factor: 4.200

2.  dynorphin-kappa opioid receptor signaling partly mediates estrogen negative feedback effect on LH pulses in female rats.

Authors:  Parvin Mostari; Nahoko Ieda; Chikaya Deura; Shiori Minabe; Shunji Yamada; Yoshihisa Uenoyama; Kei-ichiro Maeda; Hiroko Tsukamura
Journal:  J Reprod Dev       Date:  2013-02-08       Impact factor: 2.214
  2 in total

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