Literature DB >> 24277183

The analgesic activity of neo-kyotorphin: a newly identified pentapeptide from bovine brain.

K Fukui1, H Amano, Y Kiso, K Kitagawa, H Takagi.   

Abstract

Analgesic effects of a novel pentapeptide from bovine brain, termed neo-kyotorphin (Thr-Ser-Lys-Tyr-Arg), were determined in mice after intracisternal injection. Neo-kyotorphin showed a dose-dependent analgesia with an ED50 value of 195 nmol/ mouse. This effect was not blocked by naloxone pretreatment.

Entities:  

Year:  1984        PMID： 24277183     DOI： 10.1023/A:1016330726289

Source DB:  PubMed          Journal:  Pharm Res        ISSN： 0724-8741            Impact factor:   4.200


  6 in total

1.  Morphine-like analgesia by a new dipeptide, L-tyrosyl-L-arginine (Kyotorphin) and its analogue.

Authors:  H Takagi; H Shiomi; H Ueda; H Amano
Journal:  Eur J Pharmacol       Date:  1979-04-01       Impact factor: 4.432

2.  Comparison of the analgesic effects of various opioid peptides by a newly devised intracisternal injection technique in conscious mice.

Authors:  H Ueda; H Amano; H Shiomi; H Takagi
Journal:  Eur J Pharmacol       Date:  1979-06-15       Impact factor: 4.432

3.  Neurotensin: antinocisponsive action in rodents.

Authors:  B V Clineschmidt; J C McGuffin; P B Bunting
Journal:  Eur J Pharmacol       Date:  1979-02-15       Impact factor: 4.432

4.  Isolation of a novel analgesic pentapeptide, neo-kyotorphin, from bovine brain.

Authors:  H Takagi; H Shiomi; K Fukui; K Hayashi; Y Kiso; K Kitagawa
Journal:  Life Sci       Date:  1982 Oct 18-25       Impact factor: 5.037

5.  Bombesin: receptor distribution in brain and effects on nociception and locomotor activity.

Authors:  A Pert; T W Moody; C B Pert; L A Dewald; J Rivier
Journal:  Brain Res       Date:  1980-07-07       Impact factor: 3.252

6.  Isolation from bovine brain of a novel analgesic pentapeptide, neo-kyotorphin, containing the Tyr-Arg (kyotorphin) unit.

Authors:  K Fukui; H Shiomi; H Takagi; K Hayashi; Y Kiso; K Kitagawa
Journal:  Neuropharmacology       Date:  1983-02       Impact factor: 5.250
  6 in total

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