Regulation of lymphatic vasculature by extracellular matrix.

The extracellular matrix (ECM) is a complex but highly organized network of macromolecules with different physical, biochemical, and mechanical properties. In addition to providing structural support to tissues, it regulates a variety of cellular responses during development and tissue homeostasis. Interactions between the lymphatic vessels and their ECM are starting to be recognized as important modulators of lymphangiogenesis. Here, we review the current knowledge of the structure and composition of the ECM of lymphatic vessels and discuss the role of individual matrix components and their cell surface receptors in regulating lymphatic vascular development and function.