AIMS: To determine whether there is an association between retinal thinning and functional rating scales in patients with Parkinson's disease (PD). MATERIALS AND METHODS: Patients with PD (n=153) and controls (n=242) underwent evaluations of the macula and retinal nerve fibre layer (RNFL) using two new-generation Fourier domain optical coherence tomography (OCT) devices (Cirrus, Carl Zeiss Meditec, Dublin, California, USA; Spectralis, Heidelberg Engineering, Heidelberg, Germany). PD severity was assessed using the Schwab-England Activities of Daily Living scale, the Unified Parkinson Disease Rating Scale, the Hoehn and Yahr (HY) scale. Retinal and RNFL thicknesses were compared between patients and controls. Correlations between structural parameters and the scores of the neurologic scales were evaluated. RESULTS: RNFL parameters were significantly reduced in patients with PD, especially when using the Spectralis OCT device. All macular parameters, except for foveal thickness, differed significantly between controls and patients with PD (p<0.001). HY scores were significantly and inversely correlated with all macular parameters when measured with the Spectralis OCT device (p<0.05) and with RNFL thickness when measured with the Cirrus OCT device (nasal quadrant, sectors 2 and 5). CONCLUSIONS: The neurodegeneration caused by PD can be detected using Fourier domain OCT. RNFL and macular thicknesses correlate with PD severity.
AIMS: To determine whether there is an association between retinal thinning and functional rating scales in patients with Parkinson's disease (PD). MATERIALS AND METHODS:Patients with PD (n=153) and controls (n=242) underwent evaluations of the macula and retinal nerve fibre layer (RNFL) using two new-generation Fourier domain optical coherence tomography (OCT) devices (Cirrus, Carl Zeiss Meditec, Dublin, California, USA; Spectralis, Heidelberg Engineering, Heidelberg, Germany). PD severity was assessed using the Schwab-England Activities of Daily Living scale, the Unified Parkinson Disease Rating Scale, the Hoehn and Yahr (HY) scale. Retinal and RNFL thicknesses were compared between patients and controls. Correlations between structural parameters and the scores of the neurologic scales were evaluated. RESULTS: RNFL parameters were significantly reduced in patients with PD, especially when using the Spectralis OCT device. All macular parameters, except for foveal thickness, differed significantly between controls and patients with PD (p<0.001). HY scores were significantly and inversely correlated with all macular parameters when measured with the Spectralis OCT device (p<0.05) and with RNFL thickness when measured with the Cirrus OCT device (nasal quadrant, sectors 2 and 5). CONCLUSIONS: The neurodegeneration caused by PD can be detected using Fourier domain OCT. RNFL and macular thicknesses correlate with PD severity.
Authors: Carlos E Mendoza-Santiesteban; Jose-Alberto Palma; Jose Martinez; Lucy Norcliffe-Kaufmann; Thomas R Hedges; Horacio Kaufmann Journal: Mov Disord Date: 2015-09-11 Impact factor: 10.338
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Authors: Vicente Polo; Maria Satue; Alicia Gavin; Elisa Vilades; Elvira Orduna; Marta Cipres; Javier Garcia-Campayo; Mayte Navarro-Gil; Jose M Larrosa; Luis E Pablo; Elena Garcia-Martin Journal: Eye (Lond) Date: 2018-10-31 Impact factor: 3.775