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Literature DB >> 2427665

Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes with acanthocytosis: a clinicopathological study of a unique case.

M Mukoyama, H Kazui, N Sunohara, M Yoshida, I Nonaka, E Satoyoshi.

Abstract

A case of a unique combination of mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like syndrome (MELAS) with acanthocytosis is reported. Neuropathological examination revealed pellagra-like change in Betz cells, brain-stem neurons and anterior horn cells as well as findings compatible with mitochondrial encephalomyopathies. Abnormal function of nicotinic acid-related enzymes could be the cause of the complicated clinicopathologic findings in this case. This is the first report of MELAS with acanthocytosis.

Entities: Chemical Disease

Mesh：

Substances：
Lactates
Lactic Acid

Year: 1986 PMID： 2427665 DOI： 10.1007/bf00314025

Source DB: PubMed Journal: J Neurol ISSN： 0340-5354 Impact factor: 4.849

15 in total

1. Mitochondrial encephalomyopathies: a group of neuromuscular disorders with defects in oxidative metabolism.

Authors: Y Shapira; S Harel; A Russell
Journal: Isr J Med Sci Date: 1977-02

2. Hereditary neurological disease with acanthocytosis. A new syndrome.

Authors: I M Levine; J W Estes; J M Looney
Journal: Arch Neurol Date: 1968-10

3. Mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes: a distinctive clinical syndrome.

Authors: S G Pavlakis; P C Phillips; S DiMauro; D C De Vivo; L P Rowland
Journal: Ann Neurol Date: 1984-10 Impact factor: 10.422

4. Mitochondrial encephalomyopathy with lactate-pyruvate elevation and brain infarctions.

Authors: M Kuriyama; H Umezaki; Y Fukuda; M Osame; K Koike; J Tateishi; A Igata
Journal: Neurology Date: 1984-01 Impact factor: 9.910

5. Familial tic disorder, parkinsonism, motor neuron disease, and acanthocytosis: a new syndrome.

Authors: M C Spitz; J Jankovic; J M Killian
Journal: Neurology Date: 1985-03 Impact factor: 9.910

6. Abnormalities of erythrocytes in Duchenne muscular dystrophy.

Authors: M Yoshida; K Ando; E Satoyoshi
Journal: Ann Neurol Date: 1983-06 Impact factor: 10.422

7. Benign X-linked myopathy with acanthocytes (McLeod syndrome). Its relationship to X-linked muscular dystrophy.

Authors: M Swash; M S Schwartz; N D Carter; R Heath; M Leak; K L Rogers
Journal: Brain Date: 1983-09 Impact factor: 13.501

8. Mitochondrial encephalomyopathy with decreased succinate-cytochrome c reductase activity.

Authors: J E Riggs; S S Schochet; A V Fakadej; A Papadimitriou; S DiMauro; T W Crosby; L Gutmann; R T Moxley
Journal: Neurology Date: 1984-01 Impact factor: 9.910

9. Ocular myopathy (progressive external ophthalmoplegia) with neuropathic complications.

Authors: P B Croft; J C Cutting; E C Jewesbury; W Blackwood; W G Mair
Journal: Acta Neurol Scand Date: 1977-03 Impact factor: 3.209

10. Myoclonus epilepsy associated with ragged-red fibres (mitochondrial abnormalities ): disease entity or a syndrome? Light-and electron-microscopic studies of two cases and review of literature.

Authors: N Fukuhara; S Tokiguchi; K Shirakawa; T Tsubaki
Journal: J Neurol Sci Date: 1980-07 Impact factor: 3.181

14 in total

Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes with acanthocytosis: a clinicopathological study of a unique case.

1. Mitochondrial encephalomyopathies: a group of neuromuscular disorders with defects in oxidative metabolism.

2. Hereditary neurological disease with acanthocytosis. A new syndrome.

3. Mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes: a distinctive clinical syndrome.

4. Mitochondrial encephalomyopathy with lactate-pyruvate elevation and brain infarctions.

5. Familial tic disorder, parkinsonism, motor neuron disease, and acanthocytosis: a new syndrome.

6. Abnormalities of erythrocytes in Duchenne muscular dystrophy.

7. Benign X-linked myopathy with acanthocytes (McLeod syndrome). Its relationship to X-linked muscular dystrophy.

8. Mitochondrial encephalomyopathy with decreased succinate-cytochrome c reductase activity.

9. Ocular myopathy (progressive external ophthalmoplegia) with neuropathic complications.

10. Myoclonus epilepsy associated with ragged-red fibres (mitochondrial abnormalities ): disease entity or a syndrome? Light-and electron-microscopic studies of two cases and review of literature.

1. Involvement of extraocular muscle in mitochondrial encephalomyopathy.

2. Central nervous system changes in mitochondrial encephalomyopathy: light and electron microscopic study.

3. Psychiatric disturbance in mitochondrial encephalomyopathy.

4. Involvement of choroid plexus in mitochondrial encephalomyopathy (MELAS).

Review 5. Neuropathology and pathogenesis of mitochondrial diseases.

6. Mitochondrial encephalomyopathy. A variant with heart failure and liver steatosis.

7. Mitochondrial angiopathy in cerebral blood vessels of mitochondrial encephalomyopathy.

8. Mitochondrial encephalomyopathy (MELAS) with mental disorder. CT, MRI and SPECT findings.

9. An autopsy case of mitochondrial encephalomyopathy with prominent degeneration in olivo-ponto-cerebellar system.

10. Neuropathology of myoclonus epilepsy associated with ragged-red fibers (Fukuhara's disease).