BACKGROUND AND GOALS: Cystic fibrosis (CF) is associated with increased incidence of gastrointestinal cancer. Increasing overall life expectancy of CF patients predicts emergence of colon cancer as a significant clinical problem in the adult CF population. The primary aim of this study was to estimate the incidence of adenomatous colon polyps in patients with CF during systematic screening by colonoscopy. STUDY: This is a single-center series of 45 CF patients aged 40 years and above (mean age, 47 y) undergoing colonoscopic screening. A fraction of these patients (9/45) had history of organ transplantation. Results from transplant and nontransplant patients were analyzed separately. RESULTS: Adult CF patients have a high incidence of adenomatous polyps identified by colonoscopy. In addition, positive examinations are characterized by multiple polyps and common features of advanced pathology. The incidence of adenomatous colon polyps is greater in male patients, although the 1 patient in this cohort found to have colorectal cancer was female. CONCLUSIONS: CF has features of a hereditary colon cancer syndrome. Increasing life expectancy of CF patients suggests that earlier colon screening in this population may be warranted. Optimal criteria for initiation of screening and frequency of surveillance should be subject of further studies.
BACKGROUND AND GOALS: Cystic fibrosis (CF) is associated with increased incidence of gastrointestinal cancer. Increasing overall life expectancy of CFpatients predicts emergence of colon cancer as a significant clinical problem in the adult CF population. The primary aim of this study was to estimate the incidence of adenomatous colon polyps in patients with CF during systematic screening by colonoscopy. STUDY: This is a single-center series of 45 CFpatients aged 40 years and above (mean age, 47 y) undergoing colonoscopic screening. A fraction of these patients (9/45) had history of organ transplantation. Results from transplant and nontransplant patients were analyzed separately. RESULTS: Adult CFpatients have a high incidence of adenomatous polyps identified by colonoscopy. In addition, positive examinations are characterized by multiple polyps and common features of advanced pathology. The incidence of adenomatous colon polyps is greater in male patients, although the 1 patient in this cohort found to have colorectal cancer was female. CONCLUSIONS:CF has features of a hereditary colon cancer syndrome. Increasing life expectancy of CFpatients suggests that earlier colon screening in this population may be warranted. Optimal criteria for initiation of screening and frequency of surveillance should be subject of further studies.
Authors: B L N Than; J F Linnekamp; T K Starr; D A Largaespada; A Rod; Y Zhang; V Bruner; J Abrahante; A Schumann; T Luczak; A Niemczyk; M G O'Sullivan; J P Medema; R J A Fijneman; G A Meijer; E Van den Broek; C A Hodges; P M Scott; L Vermeulen; R T Cormier Journal: Oncogene Date: 2016-01-11 Impact factor: 9.867
Authors: Kevin Kim; Elizabeth A Lane; Aurelia Saftien; Haiyun Wang; Yue Xu; Frederik Wirtz-Peitz; Norbert Perrimon Journal: Proc Natl Acad Sci U S A Date: 2020-04-28 Impact factor: 11.205
Authors: Kathrin Krause; Benjamin T Kopp; Mia F Tazi; Kyle Caution; Kaitlin Hamilton; Asmaa Badr; Chandra Shrestha; Dmitry Tumin; Don Hayes; Frank Robledo-Avila; Luanne Hall-Stoodley; Brett G Klamer; Xiaoli Zhang; Santiago Partida-Sanchez; Narasimham L Parinandi; Stephen E Kirkby; Duaa Dakhlallah; Karen S McCoy; Estelle Cormet-Boyaka; Amal O Amer Journal: J Cyst Fibros Date: 2017-12-11 Impact factor: 5.482
Authors: Andrea Gini; Ann G Zauber; Dayna R Cenin; Amir-Houshang Omidvari; Sarah E Hempstead; Aliza K Fink; Albert B Lowenfels; Iris Lansdorp-Vogelaar Journal: Gastroenterology Date: 2017-11-02 Impact factor: 22.682