Literature DB >> 2427506

High temperature induction of a stringent response in the dnaK(Ts) and dnaJ(Ts) mutants of Escherichia coli.

H Itikawa, H Fujita, M Wada.   

Abstract

The cellular concentrations of ppGpp in the dnaK(Ts) and dnaJ(Ts) mutants of Escherichia coli were examined, since the thermosensitive RNA synthesis of these mutants is relaxed by an additional mutation in the relA gene. The results showed that ppGpp accumulated extensively in the dnaK(Ts) and dnaJ(Ts) mutants after a temperature shift up, reaching levels of 5 mM and 0.5 mM, respectively. This unusual accumulation of ppGpp was suppressed by the relA1 mutation, implying that it results from induction of a stringent response in these mutants at a nonpermissive temperature.

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Year:  1986        PMID： 2427506     DOI： 10.1093/oxfordjournals.jbchem.a135648

Source DB:  PubMed          Journal:  J Biochem        ISSN： 0021-924X            Impact factor:   3.387


  9 in total

1.  Cellular defects caused by deletion of the Escherichia coli dnaK gene indicate roles for heat shock protein in normal metabolism.

Authors:  B Bukau; G C Walker
Journal:  J Bacteriol       Date:  1989-05       Impact factor: 3.490

2.  DNA sequence analysis of the dnaK gene of Escherichia coli B and of two dnaK genes carrying the temperature-sensitive mutations dnaK7(Ts) and dnaK756(Ts).

Authors:  T Miyazaki; S Tanaka; H Fujita; H Itikawa
Journal:  J Bacteriol       Date:  1992-06       Impact factor: 3.490

3.  Genetic suppression of a temperature-sensitive groES mutation by an altered subunit of RNA polymerase of Escherichia coli K-12.

Authors:  M Wada; H Fujita; H Itikawa
Journal:  J Bacteriol       Date:  1987-03       Impact factor: 3.490

4.  Mutant DnaK chaperones cause ribosome assembly defects in Escherichia coli.

Authors:  J H Alix; M F Guérin
Journal:  Proc Natl Acad Sci U S A       Date:  1993-10-15       Impact factor: 11.205

5.  High levels of manganese-containing superoxide dismutase and thermally induced DNA disruption in a dnaK7(Ts) mutant of Escherichia coli K12.

Authors:  H Taniguchi; T Tokida; H Fujita; H Itikawa
Journal:  Mol Gen Genet       Date:  1989-06

6.  Roles of Escherichia coli heat shock proteins DnaK, DnaJ and GrpE in mini-F plasmid replication.

Authors:  Y Kawasaki; C Wada; T Yura
Journal:  Mol Gen Genet       Date:  1990-01

7.  Cloning and expression in Escherichia coli of the dnaK gene of Zymomonas mobilis.

Authors:  G P Michel
Journal:  J Bacteriol       Date:  1993-05       Impact factor: 3.490

8.  Characterization of SIS1, a Saccharomyces cerevisiae homologue of bacterial dnaJ proteins.

Authors:  M M Luke; A Sutton; K T Arndt
Journal:  J Cell Biol       Date:  1991-08       Impact factor: 10.539

9.  An essential nonredundant role for mycobacterial DnaK in native protein folding.

Authors:  Allison Fay; Michael S Glickman
Journal:  PLoS Genet       Date:  2014-07-24       Impact factor: 5.917
  9 in total

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