Literature DB >> 24274557

Synthesis, characterization, swelling and drug release behavior of semi-interpenetrating network hydrogels of sodium alginate and polyacrylamide.

Himadri Sekhar Samanta1, Samit Kumar Ray.   

Abstract

Several semi interpenetrating network (SIPN) type hydrogels were synthesized by in-situ free radical crosslink copolymerization of acrylamide and crosslinker N,N'-methylene bisacrylamide (MBA) in aqueous solution of sodium alginate (SA).These SIPN hydrogels were characterized by FTIR, NMR SEM, DTA-TGA, XRD, PZC and also by swelling characteristics and network parameters. Adsorption (loading) and release of acetaminophen drug were studied with these hydrogels. Solution pH, crosslinker concentration and monomer to SA weight ratio of the hydrogels were found to have a strong effect on adsorption and in vitro release profile of the drug from the gel matrix.
Copyright © 2013 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Acrylamide; Characterization; Drug release; Semi-IPN hydrgels; Sodium alginate

Mesh：

Substances：

Year:  2013        PMID： 24274557     DOI： 10.1016/j.carbpol.2013.09.004

Source DB:  PubMed          Journal:  Carbohydr Polym        ISSN： 0144-8617            Impact factor:   9.381


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