| Literature DB >> 24273133 |
Benjamin List1, Ilija Čorić, Oleksandr O Grygorenko, Philip S J Kaib, Igor Komarov, Anna Lee, Markus Leutzsch, Subhas Chandra Pan, Andrey V Tymtsunik, Manuel van Gemmeren.
Abstract
The first aminocatalyzed α-alkylation of α-branched aldehydes with benzyl bromides as alkylating agents has been developed. Using a sterically demanding proline derived catalyst, racemic α-branched aldehydes are reacted with alkylating agents in a DYKAT process to give the corresponding α-alkylated aldehydes with quaternary stereogenic centers in good yields and high enantioselectivities.Entities:
Keywords: DYKATt; enamine catalysis; organocatalysis; α-alkylation; α-branched aldehydes
Year: 2013 PMID： 24273133 DOI： 10.1002/anie.201306037
Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336