Shang-Jen Chang1, I-Ni Chiang, Chia-Da Lin, Cheng-Hsing Hsieh, Stephen Shei-Dei Yang. 1. Division of Urology, Department of Surgery, Taipei Tzu Chi Hospital, The Buddhist Tzu Chi Medical Foundation, Taipei, Taiwan; Department of Urology, School of Medicine, Buddhist Tzu Chi University, Hualien, Taiwan.
Abstract
AIMS: To investigate the association between obesity and lower urinary tract symptoms (LUTS) in healthy children. METHODS: Healthy community children (5-12 years) were enrolled to evaluate LUTS and voiding function, and classified by body mass index as being of normal weight, overweight, or obese. A questionnaire was completed by one parent of each child and included baseline characteristics, Dysfunctional Voiding Symptom Score, obstructive sleep apnea-related symptoms, stressful events, and nocturnal enuresis status in the past months. Overactive bladder (OAB) was defined by an urgency symptom score of ≥ 2. Monosymptomatic nocturnal enuresis (MNE) was defined as nocturnal enuresis without either OAB or daytime incontinence. RESULTS: A total of 838 children (mean age, 8.0 ± 2.0 years) were eligible for analysis. The prevalence of overweight and obesity was 14.0% and 10.7%, respectively, without gender disparity. Obese children had higher urgency symptom score than children of normal weight (0.87 ± 1.00 vs. 0.60 ± 0.87; P = 0.03). Multivariate analysis showed that significant risk factors for OAB were younger age (OR, 1.17; 95% CI, 1.06-1.29) and obesity (OR, 1.97; 95% CI, 1.14-3.40), while not gender, overweight, obstructive sleep apnea-related symptoms, and stressful events. Statistically significant risk factors for MNE were younger age and stressful events, while not obesity. CONCLUSIONS: Obese community children were at a higher risk of having OAB while not for MNE.
AIMS: To investigate the association between obesity and lower urinary tract symptoms (LUTS) in healthy children. METHODS: Healthy community children (5-12 years) were enrolled to evaluate LUTS and voiding function, and classified by body mass index as being of normal weight, overweight, or obese. A questionnaire was completed by one parent of each child and included baseline characteristics, Dysfunctional Voiding Symptom Score, obstructive sleep apnea-related symptoms, stressful events, and nocturnal enuresis status in the past months. Overactive bladder (OAB) was defined by an urgency symptom score of ≥ 2. Monosymptomatic nocturnal enuresis (MNE) was defined as nocturnal enuresis without either OAB or daytime incontinence. RESULTS: A total of 838 children (mean age, 8.0 ± 2.0 years) were eligible for analysis. The prevalence of overweight and obesity was 14.0% and 10.7%, respectively, without gender disparity. Obesechildren had higher urgency symptom score than children of normal weight (0.87 ± 1.00 vs. 0.60 ± 0.87; P = 0.03). Multivariate analysis showed that significant risk factors for OAB were younger age (OR, 1.17; 95% CI, 1.06-1.29) and obesity (OR, 1.97; 95% CI, 1.14-3.40), while not gender, overweight, obstructive sleep apnea-related symptoms, and stressful events. Statistically significant risk factors for MNE were younger age and stressful events, while not obesity. CONCLUSIONS:Obese community children were at a higher risk of having OAB while not for MNE.
Authors: Mustafa Suat Bolat; Sırrı S Bilge; Ekrem Akdeniz; Onder Cinar; Fatih Firat; Arzu Erdal Agri; Mustafa Bakirtas; Omer Alici; Fikret Erdemir Journal: Biomed Res Int Date: 2017-10-19 Impact factor: 3.411