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Literature DB >> 24272870

4-Acyl pyrroles: mimicking acetylated lysines in histone code reading.

Xavier Lucas¹, Daniel Wohlwend, Martin Hügle, Karin Schmidtkunz, Stefan Gerhardt, Roland Schüle, Manfred Jung, Oliver Einsle, Stefan Günther.

Abstract

Entities: Chemical

Keywords: 4-acyl pyrroles; bromodomain inhibition; drug discovery; epigenetics; virtual screening

Mesh：

Substances：
Histones
Pyrroles
Lysine

Year: 2013 PMID： 24272870 DOI： 10.1002/anie.201307652

Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336

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Cited

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25 in total

Review 1. The bromodomain: from epigenome reader to druggable target.

Authors: Roberto Sanchez; Jamel Meslamani; Ming-Ming Zhou
Journal: Biochim Biophys Acta Date: 2014-03-28

Review 2. Targeting bromodomains: epigenetic readers of lysine acetylation.

Authors: Panagis Filippakopoulos; Stefan Knapp
Journal: Nat Rev Drug Discov Date: 2014-04-22 Impact factor: 84.694

Review 3. Bromodomains in Protozoan Parasites: Evolution, Function, and Opportunities for Drug Development.

Authors: Victoria Jeffers; Chunlin Yang; Sherri Huang; William J Sullivan
Journal: Microbiol Mol Biol Rev Date: 2017-01-11 Impact factor: 11.056

Review 4. Structural features and inhibitors of bromodomains.

Authors: Jamel Meslamani; Steven G Smith; Roberto Sanchez; Ming-Ming Zhou
Journal: Drug Discov Today Technol Date: 2016-09-22

Review 5. Targeting Brd4 for cancer therapy: inhibitors and degraders.

Authors: Yingchao Duan; Yuanyuan Guan; Wenping Qin; Xiaoyu Zhai; Bin Yu; Hongmin Liu
Journal: Medchemcomm Date: 2018-08-07 Impact factor: 3.597

6. Metabolic Response to XD14 Treatment in Human Breast Cancer Cell Line MCF-7.

Authors: Daqiang Pan; Michel Kather; Lucas Willmann; Manuel Schlimpert; Christoph Bauer; Simon Lagies; Karin Schmidtkunz; Steffen U Eisenhardt; Manfred Jung; Stefan Günther; Bernd Kammerer
Journal: Int J Mol Sci Date: 2016-10-24 Impact factor: 5.923

7. Discovery, X-ray Crystallography, and Anti-inflammatory Activity of Bromodomain-containing Protein 4 (BRD4) BD1 Inhibitors Targeting a Distinct New Binding Site.

Authors: Zhiqing Liu; Yi Li; Haiying Chen; Hsien-Tsung Lai; Pingyuan Wang; Shwu-Yuan Wu; Eric A Wold; Paul G Leonard; Sarah Joseph; Haitao Hu; Cheng-Ming Chiang; Allan R Brasier; Bing Tian; Jia Zhou
Journal: J Med Chem Date: 2022-01-04 Impact factor: 7.446