Literature DB >> 24272693

Simultaneous determination of tiaramide and its metabolites by high performance liquid chromatography.

S Naito1, A Tanase, H Yoshihara, H Tominaga.   

Abstract

A simultaneous quantitative HPLC assay was developed for tiaramide hydrochloride (4-[(5-chloro-2-oxo-3(2H)-benzothiazolyl) acetyl]-1-piperazine ethanol hydrochloride) and its main metabolites, namely, 1 - [ (5-chloro-2-oxo-3 (2H) -benzothiazolyl) -acetyl]-piperazine (DETR) and 4-[(5-chloro-2-oxo-3(2H)-benzothiazolyl) acetyl] -piperazine acetic acid (TRAA). The assay was employed to determine plasma levels of tiaramide and its main metabolite, TRAA, after intravenous administration of tiaramide hydrochloride to rabbits.

Entities:  

Year:  1985        PMID： 24272693     DOI： 10.1023/A:1016319501756

Source DB:  PubMed          Journal:  Pharm Res        ISSN： 0724-8741            Impact factor:   4.200


  5 in total

1.  Anodic coulometric detection with a glassy carbon electrode in combination with reversed-phase high-performance liquid chromatography. Determination of blood levels of perphenazine and fluphenazine.

Authors:  U R Tjaden; J Lankelma; H Poppe
Journal:  J Chromatogr       Date:  1976-09-29

2.  Disposition and metabolic fate of tiaramide hydrochloride, a new anti-inflammatory agent, in the rat.

Authors:  H Noguchi; M Okui; K Noda; R Kato
Journal:  Xenobiotica       Date:  1977-08       Impact factor: 1.908

3.  Anti-inflammatory activity of tiaramide hydrochloride, 4-((5-chloro-2-oxo-3-benzothiazolinyl)acetyl)-1-piperazine ethanol hydrochloride.

Authors:  K Tsurumi; Y Hiramatsu; M Nozaki; M Hayashi; H Fujimura
Journal:  Arzneimittelforschung       Date:  1972-04

4.  Absorption, distribution, excretion and metabolism of tiaramide hydrochloride: a new anti-inflammatory drug.

Authors:  K Noda; H Noguchi; M Okui; K Tada; Y Morimoto
Journal:  Arzneimittelforschung       Date:  1972-04

5.  Species differences in metabolism of tiaramide hydrochloride, a new anti-inflammatory agent.

Authors:  H Noguchi; M Okui; K Noda; M Sugiura; Y Tanaka; R Kato
Journal:  Xenobiotica       Date:  1977-08       Impact factor: 1.908
  5 in total

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