Literature DB >> 24272686

In Vitro-in Vivo Correlation: An Unrealistic Problem.

R Hüttenrauch1, P Speiser.   

Abstract

This review demonstrates that any true in vivo - in vitro correlation cannot exist. A thorough analysis of the available results shows that any attempt to qualitatively or quantitatively correlate in vitro results with biopharmaceutical or pharmacokinetic data in humans is a chimerical problem.

Entities:  

Year:  1985        PMID： 24272686     DOI： 10.1023/A:1016355114960

Source DB:  PubMed          Journal:  Pharm Res        ISSN： 0724-8741            Impact factor:   4.200


  37 in total

Review 1.  [GENETIC CAUSES OF ABNORMAL DRUG EFFECTS].

Authors:  K J NETTER
Journal:  Internist (Berl)       Date:  1964-06       Impact factor: 0.743

2.  [Physical activity and lipid metabolism (author's transl)].

Authors:  A Wirth; G Schlierf; G Schettler
Journal:  Klin Wochenschr       Date:  1979-11-15

3.  Dose-dependent pharmacokinetics of prednisone and prednisolone in man.

Authors:  J C Loo; I J McGilveray; N Jordan; J Moffat; R Brien
Journal:  J Pharm Pharmacol       Date:  1978-11       Impact factor: 3.765

4.  Genetic control of dicumarol levels in man.

Authors:  E S Vesell; J G Page
Journal:  J Clin Invest       Date:  1968-12       Impact factor: 14.808

5.  I. Drug metabolism enzymes. Pharmacogenetics in animals and man.

Authors:  W Kalow
Journal:  Ann N Y Acad Sci       Date:  1968-07-31       Impact factor: 5.691

Review 6.  Time -- a key in experimental and practical medicine.

Authors:  H Mayersbach
Journal:  Arch Toxicol       Date:  1976-12-17       Impact factor: 5.153

7.  The assessment of the intrasubject variability in digoxin absorption in man from two oral dosage forms.

Authors:  A Yacobi; R G Stoll; G C Chao; R A Schwartz; D J Weidler; J W Ayers; E Sakmar; M Hallmark; J G Wagner
Journal:  J Clin Pharmacol       Date:  1981-07       Impact factor: 3.126

8.  Skin permeability in vivo: comparison in rat, rabbit, pig and man.

Authors:  M J Bartek; J A LaBudde; H I Maibach
Journal:  J Invest Dermatol       Date:  1972-03       Impact factor: 8.551

9.  Ascorbic acid absorption in humans: a comparison among several dosage forms.

Authors:  S Yung; M Mayersohn; J B Robinson
Journal:  J Pharm Sci       Date:  1982-03       Impact factor: 3.534

10.  Sex differences in plasma half-life of dextrorphan in rats administered dextromethorphan.

Authors:  G Ramachander; K R Bapatla; J F Emele
Journal:  J Pharm Sci       Date:  1978-09       Impact factor: 3.534
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  2 in total

1.  In vivo interpretation of in vitro effect studies with a detailed analysis of the method of in vitro transcription in isolated cell nuclei.

Authors:  R Strand; R Fjelland; T Flatmark
Journal:  Acta Biotheor       Date:  1996-03       Impact factor: 1.774

Review 2.  Perspectives of in vitro dissolution tests in establishing in vivo/in vitro correlations.

Authors:  M Siewert
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1993 Jan-Mar       Impact factor: 2.441
  2 in total

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