Drug release from suppositories.

Many studies have been carried out over the past decades on suppositories and their drug release properties. The present state of knowledge is reviewed with the conclusion that our current understanding of the in vivo performance of suppositories is deficient. It is therefore not possible to rely on in vitro data to predict in vivo performance. Suggestions are presented for future studies that are required to enhance our knowledge of suppositiories as drug delivery systems.