Literature DB >> 24272515

Chemistry of primaquine I: acylation of the quinoline ring portion.

J D McChesney1, R C Gupta.   

Abstract

Investigation of derivatization of primaquine (1) with various perfluoroacylating reagents revealed that the quinoline ring portion of the drug undergoes unexpectedly facile acylation. Chemical and spectral evidence in support of the assigned structures is presented and discussed. Results of the evaluation of these new primaquine derivatives for antimalarial activity is reported.

Entities:  

Year:  1985        PMID： 24272515     DOI： 10.1023/A:1016322207691

Source DB:  PubMed          Journal:  Pharm Res        ISSN： 0724-8741            Impact factor:   4.200


  3 in total

1.  Microbial transformation of primaquine by Candida tropicalis.

Authors:  A M Clark; C D Hufford; R C Gupta; R K Puri; J D McChesney
Journal:  Appl Environ Microbiol       Date:  1984-03       Impact factor: 4.792

2.  Primaquine: metabolism by microorganisms and 13C nuclear magnetic resonance assignments.

Authors:  A M Clark; C D Huford; J D McChesney
Journal:  Antimicrob Agents Chemother       Date:  1981-02       Impact factor: 5.191

3.  Rapid aromatic hydrogen exchange in the antimalarial primaquine.

Authors:  J D McChesney; S Sarangan
Journal:  Pharm Res       Date:  1984-07       Impact factor: 4.200
  3 in total

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