| Literature DB >> 2427191 |
J Jacob, A Schmoldt, G Grimmer.
Abstract
Thiaarenes are metabolized by liver microsomes of untreated rats predominantly to sulfones and sulfoxides. After pretreatment of rats with monooxygenase inducers, ring oxidation of thiaarenes is also observed. In case of benzo[b]naphtho[2,3-d]thiophene the formation of a p-quinone takes place. Rat liver microsomal metabolism of the thiaarenes tested as substrates did not resemble that of the polycyclic aromatic hydrocarbon (PAH) isosters at all.Entities:
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Year: 1986 PMID： 2427191 DOI： 10.1016/0304-3835(86)90045-5
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679