OBJECTIVES: This study seeks to assess and compare immunohistochemical characteristics of regenerated and pristine bone areas following surgical therapy of advanced peri-implantitis. METHODS: At ligature-induced peri-implantitis defects, the intrabony component was filled with a natural bone mineral (NBM), and the supracrestal component was treated by either an equine bone block (EB) or implantoplasty. NBM and EB were soak-loaded with rhBMP-2 or sterile saline. Membrane (i.e., native collagen) protected sites were submerged for 12 weeks. Osteocalcin (OC) and transglutaminase 2 (TG2; angiogenesis) antigen reactivity was assessed within the augmented-(AA) and pristine bone (PB) areas at non-exposed sites (n = 39 defects). RESULTS: In all groups investigated, mean OC (AA, 0.5 ± 0.4 to 1.9 ± 2.9 %/PB, 1.7 ± 2.6 to 3.5 ± 6.5 %) and TG2 (AA, 0.6 ± 0.5 to 1.3 ± 1.5 %/PB, 0.5 ± 0.5 to 1.6 ± 1.9 %) values within AA did not significantly differ from those values assessed within PB (P > 0.05, respectively). CONCLUSIONS: AA formed in different treatment groups may not be considered as qualitatively (i.e., OC and TG2) compromised bone.
OBJECTIVES: This study seeks to assess and compare immunohistochemical characteristics of regenerated and pristine bone areas following surgical therapy of advanced peri-implantitis. METHODS: At ligature-induced peri-implantitis defects, the intrabony component was filled with a natural bone mineral (NBM), and the supracrestal component was treated by either an equinebone block (EB) or implantoplasty. NBM and EB were soak-loaded with rhBMP-2 or sterile saline. Membrane (i.e., native collagen) protected sites were submerged for 12 weeks. Osteocalcin (OC) and transglutaminase 2 (TG2; angiogenesis) antigen reactivity was assessed within the augmented-(AA) and pristine bone (PB) areas at non-exposed sites (n = 39 defects). RESULTS: In all groups investigated, mean OC (AA, 0.5 ± 0.4 to 1.9 ± 2.9 %/PB, 1.7 ± 2.6 to 3.5 ± 6.5 %) and TG2 (AA, 0.6 ± 0.5 to 1.3 ± 1.5 %/PB, 0.5 ± 0.5 to 1.6 ± 1.9 %) values within AA did not significantly differ from those values assessed within PB (P > 0.05, respectively). CONCLUSIONS: AA formed in different treatment groups may not be considered as qualitatively (i.e., OC and TG2) compromised bone.
Authors: T A Owen; M Aronow; V Shalhoub; L M Barone; L Wilming; M S Tassinari; M B Kennedy; S Pockwinse; J B Lian; G S Stein Journal: J Cell Physiol Date: 1990-06 Impact factor: 6.384
Authors: Frank Schwarz; Daniel Ferrari; Martin Sager; Monika Herten; Brigitte Hartig; Jürgen Becker Journal: Clin Oral Implants Res Date: 2009-08-30 Impact factor: 5.977