Stimulation of thiamine triphosphate metabolism in nerve by cyclic guanosine 3',5'-monophosphate.

This paper reports that addition of cGMP results in an increase of the amount of(32)Pi incorporated into thiamine triphosphate in nerve roots and sympathetic trunks. The effect is present both at rest and during electrical stimulation. Other nucleotides were less effective. Theophylline increased the incorporation, possibly because of phosphodiesterase inhibition. A blocking effect of atropine was noted in sympathetic trunk preparations that contain ganglion cells.