Literature DB >> 24271246

Glutamic acid: A strong candidate as the neurotransmitter of the cerebellar granule cell.

D B Hudson1, T Valcana, G Bean, P S Timiras.   

Abstract

Free amino acids and cholinergic enzymes were investigated in the cerebellum of reeler and weaver mice in an attempt to identify the neurotransmitter characteristic of the granule cell population and to clarify any neurotransmitter abnormalities of their pre- and postsynaptic neurons induced by their depletion. The data indicate that glutamic acid may be the neurotransmitter of the granule cells. Pre- and postsynaptic neurotransmitter activity seemed not to be markedly altered in cerebellar granule cell dysgenesis.

Entities:  

Year:  1976        PMID： 24271246     DOI： 10.1007/BF00965633

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  25 in total

1.  The development of Bergmann glia in mutant mice with cerebellar malformations: reeler, staggerer and weaver. Immunofluorescence study with antibodies to the glial fibrillary acidic protein.

Authors:  A Bignami; D Dahl
Journal:  J Comp Neurol       Date:  1974-05-15       Impact factor: 3.215

Review 2.  Glutamic acid as a synaptic transmitter in the nervous system. A review.

Authors:  J L Johnson
Journal:  Brain Res       Date:  1972-02-11       Impact factor: 3.252

3.  Effects of X-radiation on the subcellular distribution of cholinergic enzymes in the developing rat cerebellum.

Authors:  T Valcana; C Liao; P S Timiras
Journal:  Brain Res       Date:  1974-06-14       Impact factor: 3.252

4.  Effects of X-radiation on the development of the cholinergic system of the rat brain. I. Study of alterations in choline acetyltransferase and acetylcholinesterase activity and acetylcholinesterase synthesis.

Authors:  T Valcana; P S Timiras
Journal:  Environ Physiol Biochem       Date:  1974

5.  Sequence of developmental abnormalities leading to granule cell deficit in cerebellar cortex of weaver mutant mice.

Authors:  P Rakic; R L Sidman
Journal:  J Comp Neurol       Date:  1973-11-15       Impact factor: 3.215

Review 6.  Cholinesterases of the central nervous system with special reference to the cerebellum.

Authors:  A Silver
Journal:  Int Rev Neurobiol       Date:  1967       Impact factor: 3.230

7.  Effects of X-irradiation on the content of amino acids in the developing rat cerebellum.

Authors:  T Valcana; D Hudson; P S Timiras
Journal:  J Neurochem       Date:  1972-09       Impact factor: 5.372

8.  On the role of glial cells in the mammalian nervous system. Uptake, excretion, and metabolism of putative neurotransmitters by cultured glial tumor cells.

Authors:  B K Schrier; E J Thompson
Journal:  J Biol Chem       Date:  1974-03-25       Impact factor: 5.157

9.  Catecholamines in mutant mouse cerebellum: fluorescence microscopic and chemical studies.

Authors:  S C Landis; W J Shoemaker; M Schlumpf; F E Bloom
Journal:  Brain Res       Date:  1975-08-08       Impact factor: 3.252

10.  A radiochemical method for the estimation of choline acetyltransferase.

Authors:  F Fonnum
Journal:  Biochem J       Date:  1966-08       Impact factor: 3.857
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  9 in total

1.  Effects of taurine on cell morphology and expression of low-affinity GABA receptors in cultured cerebellar granule cells.

Authors:  J H Abraham; A Schousboe
Journal:  Neurochem Res       Date:  1989-10       Impact factor: 3.996

2.  Development of monoamine oxidase activity and monoamine effects on glutamate release in cerebellar neurons and astrocytes.

Authors:  L Hertz; L Peng; E Hertz; B H Juurlink; P H Yu
Journal:  Neurochem Res       Date:  1989-10       Impact factor: 3.996

3.  Glutamate-like immunoreactivity revealed in rat olfactory bulb, hippocampus and cerebellum by monoclonal antibody and sensitive staining method.

Authors:  C J Liu; P Grandes; C Matute; M Cuénod; P Streit
Journal:  Histochemistry       Date:  1989

4.  Changes in the content of glutamate and GABA in the cerebellar vermis and hemispheres of the Purkinje cell degeneration (pcd) mutant.

Authors:  W J McBride; B Ghetti
Journal:  Neurochem Res       Date:  1988-02       Impact factor: 3.996

5.  Role of aspartate aminotransferase and mitochondrial dicarboxylate transport for release of endogenously and exogenously supplied neurotransmitter in glutamatergic neurons.

Authors:  G Palaiologos; L Hertz; A Schousboe
Journal:  Neurochem Res       Date:  1989-04       Impact factor: 3.996

6.  Distribution and characterization of the glutamate receptors in the CNS of ataxic mutant mouse.

Authors:  T Yamaguchi; K Hayashi; H Murakami; S Maruyama; M Yamaguchi
Journal:  Neurochem Res       Date:  1984-04       Impact factor: 3.996

7.  Neurochemical and histological analysis of motor dysfunction observed in rats with methylnitrosourea-induced experimental cerebellar hypoplasia.

Authors:  K Fujimori; K Inoue; K Nakazawa; A Maekawa; M Shibutani; A Takanaka
Journal:  Neurochem Res       Date:  1992-03       Impact factor: 3.996

8.  Free amino acids in synaptic vesicles isolated from the cerebellum and cerebral hemispheres of control and neonatally X-irradiated rats.

Authors:  T Valcana; D B Hudson; P S Timiras
Journal:  Neurochem Res       Date:  1984-10       Impact factor: 3.996

9.  Levels of glutamate, aspartate, GABA, and taurine in different regions of the cerebellum after x-irradiation-induced neuronal loss.

Authors:  M A Rea; W J McBride; B H Rohde
Journal:  Neurochem Res       Date:  1981-01       Impact factor: 3.996
  9 in total

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