Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 The effect of methionine on the uptake, distribution, and binding of the convulsant methionine sulfoximine in the rat.

Literature DB >> 24271244

The effect of methionine on the uptake, distribution, and binding of the convulsant methionine sulfoximine in the rat.

Abstract

The effect of methionine on the uptake, distribution, and binding of the convulsant methionine sulfoximine (MSO) in 7 rat brain regions, the spinal cord, the liver, and the kidney was investigated. The administration of methionine decreased the uptake of MSO in all brain regions. The uptake of MSO by and its distribution in the nervous tissue was uniform and failed to result in any preferential accumulation of the drug. Methionine decreased the amount of MSO bound to cerebral structures and to the spinal cord. MSO bound to the spinal cord was less susceptible to release by Triton X-100 than was brain-bound MSO.

Entities: Chemical Species

Year: 1976 PMID： 24271244 DOI： 10.1007/BF00965631

Source DB: PubMed Journal: Neurochem Res ISSN： 0364-3190 Impact factor: 3.996

24 in total

1. THE INHIBITION IN VIVO OF CEREBRAL GLUTAMINE SYNTHETASE AND GLUTAMINE TRANSFERASE BY THE CONVULSANT METHIONINE SULFOXIMINE.

Authors: C LAMAR; O Z SELLINGER
Journal: Biochem Pharmacol Date: 1965-04 Impact factor: 5.858

8. The influence of l-methionine-d,l-sulfoximine on the labelling of acid soluble fraction and proteins of the brain cortex after intraperitoneal injection of 14c-leucine.

Authors: V Lisý; Z Lodin
Journal: Exp Pathol (Jena) Date: 1975

9. An ultrastructural study of methionine sulphoximine-induced glycogen accumulation in astrocytes of the mouse cerebral cortex.

Authors: C H Phelps
Journal: J Neurocytol Date: 1975-08

The effect of methionine on the uptake, distribution, and binding of the convulsant methionine sulfoximine in the rat.

1. THE INHIBITION IN VIVO OF CEREBRAL GLUTAMINE SYNTHETASE AND GLUTAMINE TRANSFERASE BY THE CONVULSANT METHIONINE SULFOXIMINE.

2. The distribution of S35-labeled L-methionine sulfoximine in the rat.

3. L-methionine DL-sulphoximine and acute ammonia toxicity.

4. In vivo formation of methionine sulfoximine phosphate, a protein-bound metabolite of methionine sulfoximine.

5. The effect of methionine on the regional and intracellular disposition of [3H]-methionine sulphoximine in rat brain.

6. Methionine sulfoximine seizures. 8. The dissociation of the convulsant and glutamine synthetase inhibitory effects.

7. Glycogen, ammonia and related metabolities in the brain during seizures evoked by methionine sulphoximine.

8. The influence of l-methionine-d,l-sulfoximine on the labelling of acid soluble fraction and proteins of the brain cortex after intraperitoneal injection of 14c-leucine.

9. An ultrastructural study of methionine sulphoximine-induced glycogen accumulation in astrocytes of the mouse cerebral cortex.

10. Effect of DL-methionine sulphoximine on incorporation of 35S-methionine into proteins of brain cortex slices.

1. Effect of methionine sulfoximine on methylation of guanine residues in astroglial transfer ribonucleic acids.

2. S-Adenosyl-L-homocysteine in brain : Regional concentrations, catabolism, and the effects of methionine sulfoximine.