Literature DB >> 24271130

Change of phase-solubility behavior by gamma-cyclodextrin derivatization.

B W Müller1, U Brauns.   

Abstract

The effect of γ-cyclodextrin and its four derivatives on the solubility of progesterone in phosphate buffer pH 7.4 was investigated. γ-Cyclodextrin forms a complex precipitating from solution at low cyclodextrin concentrations. No precipitation of complexes was observed with the γ-cyclodextrin derivatives. This change in phase-solubility behavior is probably due to low crystallization tendencies of the derivatives.

Entities:  

Year:  1985        PMID： 24271130     DOI： 10.1023/A:1016301919928

Source DB:  PubMed          Journal:  Pharm Res        ISSN： 0724-8741            Impact factor:   4.200


  1 in total

Review 1.  [Pharmaceutical applications of cyclodextrin complexations (author's transl)].

Authors:  K Uekama
Journal:  Yakugaku Zasshi       Date:  1981-10       Impact factor: 0.302
  1 in total
  5 in total

1.  Pharmaceutical usefulness of hydroxypropylcyclodextrins: "e pluribus unum" is an essential feature.

Authors:  C T Rao; H M Fales; J Pitha
Journal:  Pharm Res       Date:  1990-06       Impact factor: 4.200

2.  Cyclodextrin sulfates: characterization as polydisperse and amorphous mixtures.

Authors:  J Pitha; L M Mallis; D J Lamb; T Irie; K Uekama
Journal:  Pharm Res       Date:  1991-09       Impact factor: 4.200

3.  Amorphous water-soluble cyclodextrin derivatives: 2-hydroxyethyl, 3-hydroxypropyl, 2-hydroxyisobutyl, and carboxamidomethyl derivatives of beta-cyclodextrin.

Authors:  T Irie; K Fukunaga; A Yoshida; K Uekama; H M Fales; J Pitha
Journal:  Pharm Res       Date:  1988-11       Impact factor: 4.200

4.  Effect of cyclodextrin derivatives on indomethacin stability in aqueous solution.

Authors:  T Backensfeld; B W Müller; M Wiese; J K Seydel
Journal:  Pharm Res       Date:  1990-05       Impact factor: 4.200

5.  Sulfobutylether-β-cyclodextrin.

Authors:  Valentino J Stella; Roger A Rajewski
Journal:  Int J Pharm       Date:  2020-05-04       Impact factor: 5.875
  5 in total

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