Literature DB >> 2427080

Control of PTH secretion is mediated through calcium channels and is blocked by pertussis toxin treatment of parathyroid cells.

L A Fitzpatrick, M L Brandi, G D Aurbach.   

Abstract

Parathyroid hormone secretion is negatively regulated by calcium. We utilized calcium channel agents: +202-791, a calcium channel agonist and -202-791, a calcium channel antagonist, to evaluate the role of calcium channels in PTH secretion. +202-791 inhibited PTH release from bovine parathyroid cells and the antagonist stimulated release. Incubation with pertussis toxin which ADP-ribosylates and inactivates a guanine nucleotide regulatory protein (G-protein) releases the inhibition by the calcium channel agonist. These findings indicate that a G-protein is interposed between the calcium channel and a putative intracellular site controlling PTH secretion.

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Year:  1986        PMID： 2427080     DOI： 10.1016/s0006-291x(86)80589-7

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  8 in total

1.  An acquired hypocalciuric hypercalcemia autoantibody induces allosteric transition among active human Ca-sensing receptor conformations.

Authors:  Noriko Makita; Junichiro Sato; Katsunori Manaka; Yuki Shoji; Atsuro Oishi; Makiko Hashimoto; Toshiro Fujita; Taroh Iiri
Journal:  Proc Natl Acad Sci U S A       Date:  2007-03-19       Impact factor: 11.205

2.  Gαi/o-dependent Ca(2+) mobilization and Gαq-dependent PKCα regulation of Ca(2+)-sensing receptor-mediated responses in N18TG2 neuroblastoma cells.

Authors:  John S Sesay; Reginald N K Gyapong; Leila T Najafi; Sandra L Kabler; Debra I Diz; Allyn C Howlett; Emmanuel M Awumey
Journal:  Neurochem Int       Date:  2015-07-16       Impact factor: 3.921

3.  Detection of dihydropyridine- and voltage-sensitive intracellular Ca(2+) signals in normal human parathyroid cells.

Authors:  Rinako Iida; Keitaro Yokoyama; Ichiro Ohkido; Isao Tabei; Hiroshi Takeyama; Akifumi Suzuki; Toshiaki Shibasaki; Douchi Matsuba; Norio Suda; Tatsuo Hosoya
Journal:  J Physiol Sci       Date:  2013-04-16       Impact factor: 2.781

4.  Endothelin as an autocrine factor in the regulation of parathyroid cells.

Authors:  Y Fujii; J E Moreira; C Orlando; M Maggi; G D Aurbach; M L Brandi; K Sakaguchi
Journal:  Proc Natl Acad Sci U S A       Date:  1991-05-15       Impact factor: 11.205

5.  Thapsigargin shifts the Ca set point of parathyroid cells to lower extracellular [Ca].

Authors:  T R Ferzandi; R R MacGregor
Journal:  Endocrine       Date:  1997-12       Impact factor: 3.633

6.  Antibodies to an alpha subunit of skeletal muscle calcium channels regulate parathyroid cell secretion.

Authors:  L A Fitzpatrick; H Chin; M Nirenberg; G D Aurbach
Journal:  Proc Natl Acad Sci U S A       Date:  1988-04       Impact factor: 11.205

7.  X-ray microanalysis of elemental changes in human parathyroid glands in primary and secondary hyperparathyroidism.

Authors:  R Wróblewski; H Johansson; H Johansson; L Grimelius
Journal:  Histochem Cell Biol       Date:  1996-06       Impact factor: 4.304

Review 8.  The Calcium-Sensing Receptor and the Parathyroid: Past, Present, Future.

Authors:  Arthur D Conigrave
Journal:  Front Physiol       Date:  2016-12-15       Impact factor: 4.566
  8 in total

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